We'd like your feedback
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Dr
Salomeja
Aliukaite
salomeja.aliukaite@nhs.net
John
Whittle
john.whittle2@nhs.net
More information about this study, what is involved and how to take part can be found on the study website.
Other diseases of the digestive systemArthrosis
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
250 million surgeries are carried out each year worldwide. 5% of surgeries are performed on "high-risk" patients who are at increased risk of postoperative complications or dying from surgery. Advanced age, low physical fitness, frailty, malnutrition and co-existing illness are significant predictors of adverse outcomes. Identification of these factors preoperatively can help guide medical optimisation. This study aims to explore the relationship between these risk factors and outcomes after surgery, focusing mostly on how the body uses the energy derived from different fuel sources (fat and sugar). The primary question we wish to answer is how the way the body uses fuel before surgery relates to outcomes after surgery.
The study will recruit higher-risk patients undergoing major abdominal surgery. Participants will undergo functional assessments that investigate the cardiorespiratory system and skeletal muscles. Blood samples will be taken to examine a panel of tests predicted to be related to perioperative complications that includes mitochondrial health. Frailty, health, nutrition and quality of life questionnaires will supplement the investigation.
Cardiopulmonary exercise testing (CPET) is a non - invasive measure of physical fitness. It is considered a link between heart and lung function and cellular health, (more precisely how efficiently the mitochondria- the batteries of the cell- work). We will use CPET, amongst other related tests, to help us understand how the body uses fuel when stressed. We will then follow the patient after surgery to see how their usage of fuels changes in the early postoperative period and how this reflects in changes in their body composition and mitochondrial health.
This will help us develop individualised preoperative risk assessment based on the baseline metabolic health of the patient. It will provide an in-depth understanding of the mechanisms resulting in complications and enable timely interventions.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cross-sectional;
You can take part if:
You may not be able to take part if:
- < than 18 years old. - Not able to perform CPET. - Pregnancy. - Patients without the mental capacity to consent. - Unable to ambulate independently. - Claustrophobic patients intolerant of face mask.
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
John
Whittle
john.whittle2@nhs.net
Dr
Salomeja
Aliukaite
salomeja.aliukaite@nhs.net
More information about this study, what is involved and how to take part can be found on the study website.
The study is sponsored by UNIVERSITY COLLEGE LONDON HOSPITALS NHS FOUNDATION TRUST and funded by INTERNATIONAL ANESTHESIA RESEARCH SOCIETY .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 50998
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
