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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Ischaemic heart diseasesOther forms of heart disease
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Overactivation of the immune system (also called inflammation) plays an important role in patients by causing narrowing of blood vessels leading to angina (chest tightness on exertion), heart attacks, and strokes. Furthermore, excessive and prolonged inflammation in the heart muscle after a heart attack can prevent its effective healing. Our group has shown that in animals, the over-activation of B cells, a type of immune cell, worsens heart disease. In patients, research has focused on B cells taken from blood. However, around 90% of the B cells are found in the tissues that make up a human body (including fat) and not in blood. Therefore, to help develop medicines to target B cells in heart disease we need to have a better understanding of their characteristics in both tissue and blood.
Our research study aims to address this by requesting two types of tissue from patients already planning to undergo open-heart surgery at Royal Papworth Hospital: 1) we wish to take tissue that is routinely removed during cardiac surgery and discarded. This will be mainly fat tissue around the heart and excess blood vessels. 2) We would like to take a lymph node from next to the heart. This is a pea-sized sac filled with immune cells. We will also request to take some bone fat (marrow) from the breast bone. Both of these tissues will be exposed during routine heart surgery and easily accessible.
We will study the characteristics of B cells found in these tissues, comparing them to blood, and also between patients with and without narrowing in blood vessels. Together this will allow us to have a deeper understanding of B cells in heart disease which will be important as we develop new medicines to target them in patients.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cross-sectional;
You can take part if:
You may not be able to take part if:
• Autoimmune/chronic inflammatory disease • Active infection • History of cancer that is not treated or in remission • Severe lymphopenia (< 0.2 x10^9/L) • Renal impairment (Creatinine clearance [Cockcroft-Gault] < 45ml/min) • Treatment with immunomodulatory therapies within the last month (excluding inhaled or topical steroid therapy) • Any medical condition, in the opinion of the investigator, that prevents the participant from participating in the study
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by ROYAL PAPWORTH HOSPITAL NHS FOUNDATION TRUST and funded by FONDATION LEDUCQ .
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Read full details
for Trial ID: CPMS 50929
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