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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Felicity
de Vere
felicity.de_vere@kcl.ac.uk
Aldo
Rinaldi
aldo.rinaldi@kcl.ac.uk
Other forms of heart disease
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Cardiac resynchronisation therapy (CRT) is a complex pacemaker device used to treat select patients with severe symptomatic heart failure and has been shown to improve symptoms and reduce the risk of death. Patients with atrial fibrillation (AF) do not respond as well to CRT as those in normal (sinus) rhythm as they often have fast, irregular rhythms which interrupt the pacing delivered by the CRT device. Studies have shown that the CRT device should pace at least 98% of the time (known as biventricular pacing percentage) to achieve the most benefit. There are two main options available to patients with a CRT device who have a low biventricular pacing percentage caused by AF despite taking appropriate medications. Atrioventricular (AV) node ablation involves using a catheter to ‘burn’ the AV node, which is the main electrical connection between the atria (top chambers) and ventricles (bottom chambers) of the heart. The patient remains in AF but the irregular rhythm in the atria cannot be transmitted down to the ventricles. AF catheter ablation involves using a catheter to ‘burn’ or ‘freeze’ parts of the left atrium to prevent atrial fibrillation and convert the patient back to a normal (sinus) rhythm. Currently we do not know which treatment option is best for patient with AF who have a CRT device. This study will directly compare these two interventions with the aim of determining which one is better at improving patients’ response to CRT.
Patients who have an existing CRT device and a low biventricular pacing percentage caused by AF will be recruited at 10 sites across the UK, including the primary site Guys and St Thomas' NHS Foundation Trust (GSTT). They will be randomised to either AF catheter ablation or AV node ablation and will be followed up at 6 months to determine which intervention is superior.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Interventional type: Complex Intervention;
You can take part if:
You may not be able to take part if:
1. Life expectancy < 1 year 2. Presence of atrial or ventricular thrombus 3. Permanent atrial fibrillation 4. Severe peripheral vascular disease 5. Female participants who are pregnant, lactating or planning pregnancy during the course of the study. 6. Participation in other studies with active treatment / investigational arm
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by GUY'S AND ST THOMAS' NHS FOUNDATION TRUST and funded by BRITISH HEART FOUNDATION .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 48288
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