We'd like your feedback
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Lois
Vesty-Edwards
lois.vesty-edwards@ndorms.ox.ac.uk
Prof
Stephanie
Dakin
stephanie.dakin@ndorms.ox.ac.uk
Kim Elizabeth
Wheway
kim.wheway@ndorms.ox.ac.uk
Prof
Stephanie
Dakin
stephanie.dakin@ndorms.ox.ac.uk
Jonathan
Rees
jonathan.rees@ndorms.ox.ac.uk
Other soft tissue disordersInjuries to the shoulder and upper arm
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
Musculoskeletal diseases including those affecting the shoulder are a common and significant global disease
burden in our ageing population. Diseases of the shoulder including adhesive capsulitis are often characterized by
pain and progressive shoulder immobility. Adhesive capsulitis, or Frozen Shoulder as it is commonly known, is often
very disabling, impeding activities of daily living and frequently prevents the maintenance of a fit and healthy lifestyle.
The symptoms associated with the disease usually resolve over time leading to functional recovery, however the
duration of the symptoms may be two years or more. Furthermore, a significant proportion of patients have ongoing
symptoms in the long term.
Inflammation and fibrosis is known to contribute to the development of the disease but the precise mechanisms are
not fully understood. The focus of this project is to improve understanding of the underlying biological processes, an
improved understanding of the biological basis behind fibrosis and inflammation will provide insights into new
treatment strategies for symptomatic patients. The findings from this research will be translated to advance
therapeutic approaches to target fibrosis and inflammation in patients with other common musculoskeletal diseases.
Specifically, we aim to identify and characterize the distinct populations of immune and stromal cells present in both
normal and chronically inflamed diseased capsular tissue and, importantly, determine how the presence of immune
cells influence resident fibroblast cells in shoulder tissues to improve our understanding of the type of inflammation
present in adhesive capsulitis. The project will involve collection of capsular tissue from patients undergoing planned
shoulder procedures as part of their routine clinical care pathway. This tissue will then be studied using cutting edge
laboratory techniques.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cohort study;
You can take part if:
You may not be able to take part if:
The participant may not enter the study if ANY of the following apply: • significant osteoarthritis • Rheumatoid arthritis • Patient is receiving anticoagulant therapy • Other factors that, in the opinion of the responsible clinician, might jeopardise the safe and ethical conduct of participant care, study operations or other research projects
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Prof
Stephanie
Dakin
stephanie.dakin@ndorms.ox.ac.uk
Lois
Vesty-Edwards
lois.vesty-edwards@ndorms.ox.ac.uk
Kim Elizabeth
Wheway
kim.wheway@ndorms.ox.ac.uk
Jonathan
Rees
jonathan.rees@ndorms.ox.ac.uk
Prof
Stephanie
Dakin
stephanie.dakin@ndorms.ox.ac.uk
The study is sponsored by University of Oxford and funded by NIHR Oxford Biomedical Research Centre .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 46757
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
