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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Prof
Keir
Lewis
Keir.lewis@wales.nhs.uk
Dr
Thomas
Wilkinson
t.s.wilkinson@swansea.ac.uk
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Bacterial sepsis (blood poisoning) is a huge concern to local Heath Boards in South West Wales and the UK. Conservative estimates in Wales alone have suggested the equivalent of 1800 deaths at a cost of £125 million annually. Increased levels of bacteria (e.g Escherichia coli) in the blood are often caused by ‘leaky’ barriers in the intestines, bladder and lungs, together with an inherent ability of the bacteria to cross from local tissues to the blood. To address this problem, our laboratory has been working with the Hywel Dda University Health Board. To date we have established a collection of important E. coli bacteria (n=101) that have been isolated by blood culture from patients with sepsis and are investigating the differences between these isolates, both in their inherent genetic content and how they generate immune responses in laboratory models of sepsis. Next we would like to analyse the patient records associated with the bacterial isolates to investigate ‘risk factors’ for the development of sepsis and link bacterial properties with patient parameters. We will do this in two phases where phase 1 will investigate patient data associated with our current collection of 101 E. coli isolates and phase two will investigate patient data associated with 200 new isolates to be collected in the future. Our over-arching hypothesis states that E. coli isolates most likely to cause sepsis can be predicted (and therefore treated) before blood poisoning. This project will identify important new early bacterial markers, immune responses and patient risk factors that will better predict bacterial sepsis. Our consortium of experts includes academics from Swansea University Medical School (SUMS), clinical academics and microbiologists, research and development teams from the Hywel Dda University Health Board, and a Welsh government-funded genomic centre and access to core facilities for sensitive recording of cellular responses.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Not Specified;
You can take part if:
You may not be able to take part if:
• Children and neonates will not form part of the study
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by Swansea University and funded by Health and Care Research Wales .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 46391
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