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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Valentina
Mancini
valentina.mancini@ndcn.ox.ac.uk
Hayriye
Cagnan
hayriye.cagnan@ndcn.ox.ac.uk
Ashwini
Oswal
ashwini.oswal@ndcn.ox.ac.uk
Extrapyramidal and movement disorders
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Tremor can be both physically and socially challenging. By far the two commonest causes are Essential tremor and Parkinson’s. Oral medication is available but many patients eventually discontinue the drugs used for tremor, due to limited efficacy and unacceptable side effects. For those with severe symptoms, deep brain stimulation can be effective. However, this is not without expense, risk or side-effects, and its effectiveness may reduce over time.
Accordingly, there is a need for less invasive stimulation approaches than deep brain stimulation for tremor treatment, and the goal of this study is to investigate the potential of an intervention aimed at the surface of the brain, the cerebral cortex.
We plan to test whether such a treatment would work using transcranial magnetic stimulation timed to particular points in the tremor. By doing this we hope to consistently catch the brain oscillation responsible for tremor at the point which leads to a decrease in the amplitude of the tremor. We will use magnetic stimulation because it can be safely applied from outside the brain and scalp, and involves minimal discomfort. We aim to test patients with tremor due to Parkinsons or Essential tremor. We will recruit participants through adverts placed by the National Tremor Foundation and Parkinson's UK, and through DeNDRoN.
The detection of tremor suppression using non-invasive transcranial magnetic stimulation might in the future motivate trials of stimulation delivered by minimally invasive electrodes chronically placed over the surface of the relevant part of the brain.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Type: Device;
You can take part if:
You may not be able to take part if:
o Lack of capacity to consent (judged by the researcher taking consent as not having sufficient mental capacity to understand the study and its requirements). o Concurrent involvement in another research study. o Presence of one or more contra-indications on completing the TMS Screening Form as summarised below: o History or current psychiatric illness. o History or current neurological condition (e.g. epilepsy). o History of fainting. o Presence of cochlear implant. o Presence of metal in the brain or skull. o Presence of a cardiac pacemaker or intracardiac device.
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Hayriye
Cagnan
hayriye.cagnan@ndcn.ox.ac.uk
Ashwini
Oswal
ashwini.oswal@ndcn.ox.ac.uk
Valentina
Mancini
valentina.mancini@ndcn.ox.ac.uk
The study is sponsored by University of Oxford and funded by Medical Research Council (MRC) .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 45210
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