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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Michael
Mills
mmills@sgul.ac.uk
Michael
Mills
mmills@sgul.ac.uk
Dr
kristiana
gordon
kristiana.gordon@stgeorges.nhs.uk
Stephanie
Wilken-Smith
stephanie.wilkensmith@stgeorges.nhs.uk
Other congenital malformationsDiseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
The lymphatic system is the body’s defense system that is vital for immune responses and maintaining tissue and body fluid levels. When the lymphatic system fails, accumulation of protein rich fluid (lymph) in the tissues creates chronic swelling, oedema, in an area of the body.
Primary lymphatic dysplasia are a varied group of conditions due to an underlying abnormality in the lymphatic system which can affect its function and structure. Imaging the lymphatic vessels will allow greater understanding of the issues affecting the lymphatic system and how the disease manifests. There is already a clinical standard investigation for imaging the lymphatic system, lymphoscintigraphy, however limitations in this technique mean that only course image detail can be achieved. Magnetic Resonance Lymphography (MRL) may be able to provide, in much greater detail, information relating to the structure and function of the lymphatic vessels. We also plan to compare and combine the findings of MRL with other imaging techniques to see how they can be used together to build up a fuller picture of the lymphatic system.
Examination of patients (recruited at St George's NHS foundation Trust (SGH), Lymphovascular outpatient clinic) with known genetic abnormality which alters their lymphatic system, will provide additional knowledge of how these genetic variations effect their lymphatic system. We also hope that by imaging affected individuals without a genetic diagnosis that we may be able to uncover new groups of lymphatic disorders which may then assist the search for a genetic cause and subsequently guide therapeutic interventions. We aim to recruit 30 affected individuals. These images will be compared to those that are not affected (e.g healthy individuals)-we aim to recruit 20 unaffected individuals. All scans will take place at SGH, by NHS staff, but in St George's University bought scanner time. This has been a long standing collaboration/agreement.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Validation of investigation /therapeutic procedures;
You can take part if:
You may not be able to take part if:
1. Pregnancy or suspected pregnancy. 2. Unable to provide written consent 3. Exclusion based on standard MRI safety questionnaire 4. Other current active medical condition which the involved clinical care team considers a risk for entering the study 5. Breast feeding. 6. Active infection / cellulitis.
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Dr
kristiana
gordon
kristiana.gordon@stgeorges.nhs.uk
Michael
Mills
mmills@sgul.ac.uk
Michael
Mills
mmills@sgul.ac.uk
Stephanie
Wilken-Smith
stephanie.wilkensmith@stgeorges.nhs.uk
The study is sponsored by St. George's Hospital Medical School and funded by Medical Research Council (MRC) .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 45028
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
