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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Hypertensive diseases
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High blood pressure (hypertension) is a major problem worldwide. Blood pressure is created by the force of blood against the vessel, and if this pressure remains continuously high it would put extra strain on the heart and vessels. This can increase the risk of a heart attack, stroke, or even kidney disease. There are medicines available to treat high blood pressure, but this may have side effects. Therefore, it is important to investigate and develop new alternative treatments. There is a chemical called sodium nitrite that has been shown to improve the function of the blood vessel, and we have discovered a new mechanism in how sodium nitrite lowers blood pressure. We would like to test this new mechanism in biopsies and blood samples obtained from healthy volunteers and patients who suffer from high blood pressure so that we can investigate sodium nitrite as an alternative treatment for high blood pressure.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Validation of outcome measures;
You can take part if:
You may not be able to take part if:
Exclusion Criteria: 1 Pregnant patients or breast feeding 2. People with BMI ≥40 3. Unable to provide written informed consent 4. Patients taking nitrate medication (e.g. nitrate including GTN, ISBN) 5. Severe chronic kidney disease (estimated eGFR <30) 6. Severe liver disease 7. Drug or alcohol abuse 8. Inflammatory disease (e.g. rheumatoid arthritis, systemic lupus) 9. Chronic heart failure (routine echo not required)
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by University of Birmingham and funded by BRITISH HEART FOUNDATION .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 44675
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