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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Dr
Jayanth
Arnold
Jra14@le.ac.uk
Dr
Jayanth
Arnold
Jra14@le.ac.uk
Dr
Jayanth
Arnold
Jra14@le.ac.uk
Ischaemic heart diseases
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
Coronary heart disease is the leading cause of death and disability in the UK. Restricted blood flow to the heart causes chest pain or sometimes a heart attack. Good treatments are available but we first need to identify who has a problem. We can use an invasive test called a ‘coronary angiogram’: to identify any blood vessel narrowings or blockages. However, the test can be painful, and there is a risk of things going wrong. Therefore, guidelines recommend using scans first, as they are safer and less unpleasant.
It remains uncertain which is the most accurate type of scan. National guidelines currently recommend a specific scan called ‘computed tomography coronary angiography’, or CTCA. This helps to rule out disease in some patients who don’t have a problem. However, about half the patients who don’t have a problem will also seem to have something wrong according to this scan. This can be very worrying for patients, especially as they may then need a ‘coronary angiogram’ test to check if they really do have a narrowing .
Computed tomography fractional flow reserve (CT-FFR) is an exciting new test which uses a supercomputer to analyse the CTCA scan pictures. A few studies involving carefully selected patients show that this is more accurate than using a CTCA scan alone. However, before we start using it more widely (which means the NHS needs many more scanners), we need to compare it with other types of scans. Currently, the best performing is a heart magnetic resonance imaging (MRI) scan. A bonus with MRI is that it doesn’t use radiation, and recent innovations may make it even more accurate.
Our study will determine which approach is more accurate, benefitting patients and the NHS by helping avoid unnecessary unpleasant tests which require hospital admission.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cross-sectional;
You can take part if:
You may not be able to take part if:
Recent acute coronary syndrome (< 6 months) Severe claustrophobia Absolute contraindications to CMR - those with MR conditional or safe devices will be included Second-/third-degree atrioventricular block Severe chronic obstructive pulmonary disease Moderate-severe asthma Estimated glomerular filtration rate < 30 ml/min/1.73m2 Women who are pregnant, breast-feeding or of child-bearing potential (premenopausal women) Contraindication to iodinated contrast Participants who have participated in a research study involving an investigational product in the past 12 weeks Patients unable to understand written English
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by University of Leicester and funded by NIHR Academy .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 43280
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
