We'd like your feedback
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Ms
Amber
Good
Amber.good@phri.ca
Mr
Serban
Stoica
serban.stoica@uhbristol.nhs.uk
More information about this study, what is involved and how to take part can be found on the study website.
Other forms of heart disease
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
Heart valves help control blood flow through the heart and, if diseased, may need to be replaced. After having a heart valve replaced, patients have a higher risk of death than people who have not had a valve replaced. In young adult patients, replacing the aortic heart valve with a mechanical valve halves their life-span compared to other people their age. Mechanical valves tend to form blood clots so they need long-term blood thinners that increase risk of bleeding and lower quality of life. Animal tissue valves reduce clotting and bleeding risks but wear out sooner and shorten patient life-span. An operation, called the Ross procedure, replaces a patient’s diseased aortic valve with his/her own pulmonary valve and uses a donor valve in the pulmonary position which receives less stress than the aortic valve. The Ross procedure aims to improve valve durability with less clotting, avoiding use of blood thinners. REVIVAL is a research study investigating the efficacy and safety of the Ross procedure compared to conventional valve replacement. Specifically we are interested in learning the number of patients who survive without a life-threatening valve related complication, long term postoperatively.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Interventional type: Surgery;
You can take part if:
You may not be able to take part if:
We will exclude patients meeting any of the following criteria: 1) Previous valve replacement not in the aortic position 2) Patients undergoing concomitant CABG or other valve procedure during AVR 3) Known connective tissue disease 4) Severe (grade 3 or 4) right or left ventricular dysfunction 5) Pulmonary valve dysfunction or anomalies non-compatible with the Ross procedure (as determined by the consulting cardiac surgeon) 6) Life expectancy less than 5 years (as determined by the consulting cardiac surgeon) 7) Documented severe aortic insufficiency not solely based on leaflet problem 8) Previous intervention on the pulmonary valve
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Mr
Serban
Stoica
serban.stoica@uhbristol.nhs.uk
Ms
Amber
Good
Amber.good@phri.ca
More information about this study, what is involved and how to take part can be found on the study website.
The study is sponsored by Population Health Research Institute and funded by Canadian Institutes of Health Research .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 43023
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
