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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Dr
Frank
McCaughan
fm319@cam.ac.uk
Ms
Jacqui
Galloway
jacqui.galloway@addenbrookes.nhs.uk
Chronic lower respiratory diseases
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
The purpose of this study is to develop new cell cultures and try to create laboratory models of lung disease. The hope is that these will be useful in testing new treatments. The cells and culture systems will be shared with academic and industry colleagues in the UK and abroad to increase our chances of success and of developing new treatments.
The Key Question
Can we develop laboratory models of airways disease that represent a patient’s disease and can be used to develop new treatments?
What are we going to do to answer this question?
Cells removed from patients will be grown in the laboratory and used for experiments including molecular tests and changing the levels of genes of interest or altering their function. We will then assess whether the cells taken from the airway are different between patients, and by working with academic and industry colleagues we will be able to test treatment options.
Why is this study important?
Currently available treatments for COPD often don’t work very well. There is a huge need to make more effective treatments that match individual patients’ needs.
What is the procedure and the associated risks?
Patients who are undergoing flexible bronchoscopy as part of routine care will be invited to have extra samples taken. These will include samples of the airway wall (biopsies), and airway cells (by brushing the wall) and a single blood test. These are routine procedures and the risk of significant complications is very low (less than 1%).
Who will be recruited and where?
Patients with COPD who will be having a bronchoscopy as part of their care in the COPD service of Cambridge University Hospitals NHS Trust will be recruited.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Clinical Laboratory Study;
You can take part if:
You may not be able to take part if:
1. Deemed medically unfit for bronchoscopy for any reason. 2. Clinical suspicion of cancer on CT thorax. 3. Platelet count < 50; or anticoagulation/antiplatelet medication not discontinued as per standard bronchoscopy practice.
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST and funded by Medical Research Council (MRC) .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 42995
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
