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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Dr Emily Haseler
None provided
Emily.haseler@kcl.ac.uk


Dr Manish Sinha
None provided
manish.sinha@gstt.nhs.uk


Dr Emily Haseler
None provided
Emily.haseler@kcl.ac.uk


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Be Part of Research - Trial Details - What causes high blood pressure in young people: the heart or blood vessels?
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What causes high blood pressure in young people: the heart or blood vessels?

Recruiting

Open to: All Genders

Age: Mixed

London

Medical Conditions

Paediatrics and cardiology

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Around a third of the adult population suffers from high blood pressure (medically known as “hypertension”). If left untreated, hypertension is a major risk factor for having a heart attack or a stroke. More and more children are being diagnosed with high blood pressure with no obvious cause. This is partly because doctors are checking for it more, but also because it is a common problem that develops alongside being overweight. Not much is known about what causes hypertension in children. This research aims to address this gap by looking in detail at a group of hypertensive children and young adults and comparing them to a group with normal blood pressure. The study will use state-of-the-art blood pressure measurements and heart scans to measure the flow of blood in the heart and blood vessels of participants. The study will also manipulate some of the messages getting from the brain to control the heart and blood vessels and measure the effect of these.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

01 Sep 2023 31 Aug 2026

The study involves having two different types of heart scan: an echocardiogram and an MRI scan, plus some detailed blood pressure measurements including whilst doing a slow breathing exercise for about 15 minutes. The team will also collect blood and urine samples (optional for healthy participants).


Around a third of the adult population suffers from high blood pressure (medically known as “hypertension”). If left untreated, hypertension is a major risk factor for having a heart attack or a stroke. More and more children are being diagnosed with high blood pressure with no obvious cause. This is partly because doctors are checking for it more, but also because it is a common problem that develops alongside being overweight. Not much is known about what causes hypertension in children. This research aims to address this gap by looking in detail at a group of hypertensive children and young adults and comparing them to a group with normal blood pressure. The study will use state-of-the-art blood pressure measurements and heart scans to measure the flow of blood in the heart and blood vessels of participants. The study will also manipulate some of the messages getting from the brain to control the heart and blood vessels and measure the effect of these.

Who can participate?
Children and young adults with primary hypertension aged 10 to 35 years old and under the care of specialist teams at St Thomas’ Hospital and Evelina London Children’s Hospital. Children and young adults who are healthy with normal weight and normal blood pressure aged 10 to 35 years old.

You can take part if:



You may not be able to take part if:


1. Secondary hypertension2. Clinical urgency to commence anti-hypertensive or unable to stop anti-antihypertensives for 2 week washout period3. Unable to obtain adequate quality of planned cardiovascular investigations4. Congenital heart disease5. Cardiac dysrhythmias6. Pregnancy or lactating mothers

Additional exclusion criteria for medication 1 (bisoprolol challenge):7. Asthma currently treated with medication8. Cardiac conduction abnormalities9. Known intolerance to bisoprolol

Additional exclusion criteria for medication 2 (amlodipine challenge):10. History of angina or myocardial infarction11. Known intolerance to amlodipine


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • St Thomas' Hospital
    Westminster Bridge Road
    London
    SE1 7EH

There are no direct benefits to you from taking part. You will be contributing to research that will improve understanding of high blood pressure which may benefit people of all ages with high blood pressure in the future.
There are no serious risks we anticipate in this study. The main drawbacks of taking part are the extra time and inconvenience for you to visit the hospital for the research study and the discomfort you may experience in the MRI scanner and having a blood test.

Dr Manish Sinha
None provided
manish.sinha@gstt.nhs.uk


Dr Emily Haseler
None provided
Emily.haseler@kcl.ac.uk


Dr Emily Haseler
None provided
Emily.haseler@kcl.ac.uk



The study is sponsored by King's College London and funded by Medical Research Council.



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What will you do next?
Read full details for Trial ID: ISRCTN96138097

Or CPMS 55164

Last updated 09 August 2023

This page is to help you find out about a research study and if you may be able to take part

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