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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Dr
Hans Michael
Haitchi
hmha@soton.ac.uk
Ms
Agnieszka
Burtt
Agnieszka.Burtt@uhs.nhs.uk
Chronic lower respiratory diseases
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Does illness of the mother during pregnancy such as allergic asthma have an effect on the unborn child to develop asthma in early life?
Background: In the UK, asthma is found in 1 in 11 children and often from allergic/asthmatic mothers, suggesting that disease is inherited through the genes from our parents. One of these asthma genes, ADAM33, makes an enzyme that is normally attached to cells in the airway muscle. In people with asthma the ADAM33 enzyme loses its anchor to the cell surface and is released into the lung.
We know from our animal studies that if mothers suffer from allergic airway inflammation the released form of ADAM33 protein is increased in the amniotic fluid, which surrounds the babies and fills their lungs in the womb. We do not know if this is also the case in human asthma.
The aim of this basic science study is to better understand how illnesses such as allergic asthma during pregnancy induce factors such as ADAM33 in the womb that have an effect on the development of asthma.
We will collect different body fluids and tissues before, during and after a routinely planed operation (Caesarean section) in which the baby is delivered out of the womb at the University Hospital Southampton NHS Foundation Trust. These research samples are blood, urine, amniotic fluid, tissue from umbilical cord and placenta (tube and vascular organ that connect baby with mother in the womb) that provide oxygen and nutrients to the baby. These samples are normally thrown away.
We will compare samples from healthy mothers and mothers with allergy/asthma or other illnesses during pregnancy. By studying factors such as ADAM33 we will better understand how these factors might influence the development of lung disease and how we could possibly prevent asthma in early life.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cohort study;
You can take part if:
You may not be able to take part if:
1. maternal age less than 18 years at the time of consent 2. placenta previae or other obstetric complication meaning collection of amniotic fluid difficult or likely to prolong caesarean procedure (at the discresion of PI) 3. Confirmed ruptured membranes 4. Confirmed maternal systemic sepsis 5. Significant antenatal or postnatal fetal / neonatal abnormality meaning data collection and or follow up difficult, onerous or complicated
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST and funded by ASTHMA UK .
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Read full details
for Trial ID: CPMS 41003
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