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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
NAZ
IQBAL
nazalie.iqbal1@nhs.net
NAZ
IQBAL
nazalie.iqbal1@nhs.net
Mr
David
Langton
Djlangton22@doctors.org.uk
Raghavendra
Sidaginamale
r.sidaginamale1@nhs.net
Complications of surgical and medical care, not elsewhere classified
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The production of prosthetic joints that will consistently outlive the patient remains the ultimate goal of arthroplasty. Conventional metal on polyethylene hip replacements have proven, reliable results but are less successful in younger, active patients. This is because polyethylene wear debris can stimulate a cascade of events leading to osteolysis, loosening and joint failure. It has been shown that this process is directly related to the volume of wear debris produced at the articulating surface. Failure of a joint replacement leads to removal and a new replacement to be fitted. This is termed a “revision.” Revision surgery is more challenging than primary hip replacement for both surgeon and patient. There is a significantly increased mortality rate and, even if the procedure goes uneventfully, dislocation rates have been reported to be as high as 30%.
For this reason, a number of different bearing surface combinations have been tried in an attempt to increase the longevity of hip replacements. These combinations include ceramic on ceramic, ceramic on polyethylene, ceramic on metal and metal on metal. Our previously approved protocol focused on the study of failed metal on metal hips. In this ongoing study we have shown that a number of these types of hips wear at a much greater rate than expected. This accelerated wear can leave the patient at risk of local complications including bone, nerve and muscle damage. Unfortunately we have identified a particular problem at the junction of the femoral head and the femoral stem. This is commonly termed the “taper junction”. We suspect that industry wide design modifications which have taken place in the last ten are putting other conventional types of hips at risk of taper failure.
We would therefore like to study all types of hip replacements at our centres in Newcastle University, University of Surrey, Freeman Hospital, University Hospital of North Tees. Furthermore, the routine analysis of more types of hips will allow us to determine which types of bearing materials are associated with the lowest wear rates.
Apart from issues related to wear, prosthetic hips also have a much greater risk of dislocation. Dislocation is incredibly painful and distressing and can become a recurrent problem requiring revision surgery. Again, patients are told to avoid putting their legs in particular “at risk” positions, positions which are not beyond those of activities of normal daily living. The analysis of failed hip replacements in conjunction with the assessment of the position in which the component was placed in the pelvis will allow us to explore the link between dislocation and component orientation in a large number of patients with the added knowledge that wear analysis will provide to this area of investigation.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Validation of investigation /therapeutic procedures;
You can take part if:
You may not be able to take part if:
No exclusion criteria.
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
NAZ
IQBAL
nazalie.iqbal1@nhs.net
Mr
David
Langton
Djlangton22@doctors.org.uk
Raghavendra
Sidaginamale
r.sidaginamale1@nhs.net
NAZ
IQBAL
nazalie.iqbal1@nhs.net
The study is sponsored by NORTH TEES AND HARTLEPOOL NHS FOUNDATION TRUST and funded by BRITISH ORTHOPAEDIC FOOT & ANKLE SOCIETY .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 40478
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