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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Edith
Bothway
probit@aston.ac.uk
Prof
Amanda
Wood
a.wood4@aston.ac.uk
Study
Team
probit@aston.ac.uk
More information about this study, what is involved and how to take part can be found on the study website.
Other disorders of the nervous systemInjuries to the head
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The impact of insults to the developing brain upon cognition and behavior has far-reaching consequences for the child, their family, education and healthcare systems, and government expenditure. Many variables (illness, environmental) contribute to different outcomes following similar insults, and they exert their influence via the child’s developing brain. Predicting which child will recover from an early brain insult and identifying those at risk of poor outcome represents a major challenge, with significant health economic implications. An unexplored question is whether direct measurement of the structure and function of the developing brain can improve our ability to predict outcomes in the long-term. Thus, PROBIt aims to assess the utility of brain imaging biomarkers to predict individual neuropsychological and neurobehavioral outcomes following pediatric brain injury, and to identify those factors that combine optimally to classify outcomes.
PROBIt-RetroKids will recruit 225 children (75 controls and 150 cases) who had MRI scans taken at Birmingham Children’s Hospital between 2003 and 2017. Children will be aged 6 to 15 years at the time of recruitment. We will ask for permission to acquire all their previous brain imaging data and will conduct post-scan follow-up assessments of cognitive and behavioral outcomes.
PROBIt combines data from clinically relevant pediatric cognitive and behavioral tests, brain scans and computer simulations in large groups of children with brain insults. A statistical model will be used to differentiate between children that are likely to develop with either a 'poor' or 'good' outcome across three domains: achievement, behavior and cognitive ability. First, we will determine whether adding brain imaging measures to the model improves the accuracy of prediction at the individual child level. Second, we will identify the features that confer risk and resilience to ‘good’ and ‘poor’ neurodevelopmental outcomes, which has important implications for clinical diagnosis and rehabilitation of children with early brain insults.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cohort study;
You can take part if:
You may not be able to take part if:
Early Brain injury cases Participants will be ineligible if: • The families’ English skills would require an interpreter • The child dissents Controls Participants will be ineligible if: • The families’ English skills would require an interpreter • The child has been diagnosed with developmental delay or a neurodevelopmental disorder (e.g. autism spectrum conditions) • The child dissents
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Study
Team
probit@aston.ac.uk
Prof
Amanda
Wood
a.wood4@aston.ac.uk
Edith
Bothway
probit@aston.ac.uk
More information about this study, what is involved and how to take part can be found on the study website.
The study is sponsored by Aston University and funded by European Commission .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 38755
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