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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Dr
Annina
Schmid
annina.schmid@ndcn.ox.ac.uk
Dr
Annina
Schmid
annina.schmid@ndcn.ox.ac.uk
Dr
Annina
Schmid
annina.schmid@ndcn.ox.ac.uk
Polyneuropathies and other disorders of the peripheral nervous system
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Peripheral neuropathy (injury to peripheral nerve fibres) and can be caused for instance by mechanical nerve compression (e.g., entrapment neuropathies), metabolic neuropathies (e.g., diabetes mellitus) or genetic neuropathies (e.g., channelopathies).
A subset of patients with a neuropathy develops nerve related (neuropathic) pain. Why some individuals develop neuropathic pain as a consequence of peripheral neuropathy and others do not is currently unclear. The PIPL study will help us to determine whether factors such as the severity of neuropathy, psychological factors or genetic predisposition may explain why some patients do or do not develop neuropathic pain.
Despite invasive (e.g., surgery) or conservative management (e.g., physiotherapy, medication), many patients continue to suffer from chronic neuropathic pain. Currently, the prognosis and prognostic factors for pain persistence remain unclear due to the lack of longitudinal cohort studies. PIPL will enable us to determine the prognosis of nerve dysfunction and neuropathic pain and to identify potential prognostic factors in patients with different peripheral neuropathies.
The main questions for the PIPL study are:
1. To prospectively evaluate prognostic factors for pain persistence in patients with different peripheral neuropathies
2. To assess the temporal profile of neuropathy and neuropathic pain in patients with different peripheral neuropathies
3. To identify differences in phenotype and genotype of patients with peripheral neuropathies with and without neuropathic pain
In order to achieve these goals, we will include both a cross sectional and longitudinal cohort of patients with different peripheral neuropathies and healthy volunteers. They will all undergo a detailed examination using questionnaires, nerve conduction studies, sensory testing, nerve fibre analysis in skin biopsies and genetic testing in blood samples.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cohort study;
You can take part if:
You may not be able to take part if:
Exclusion Criteria for patient participants The patient participants may not enter the study if ANY of the following apply: • Subjects who are pregnant. • Subjects with insufficient command of English to obtain consent from or to complete the study questionnaires. • Subjects with insufficient mental capacity to obtain consent from or complete study questionnaires. • Subjects with concurrent severe psychological or psychiatric disorders. • Patients with moderate to severe pain from other causes that may confound assessment or reporting of pain (eg. spinal canal stenosis). • Patients with central nervous lesions, which may complicate somatosensory testing. • Patients who are in the opinion of the investigator unsuitable for participation in the study. Exclusion Criteria for healthy participants The healthy participants may not enter the study if ANY of the following apply: • Subjects who are pregnant. • Subjects with insufficient command of English to obtain consent from or to complete the study questionnaires. • Subjects with insufficient mental capacity to obtain consent from or complete study questionnaires. • Subjects with concurrent severe psychological or psychiatric disorders. • Subjects with moderate to severe pain from other causes that may confound assessment or reporting of pain (eg. spinal canal stenosis). • Subjects with central nervous lesions, which may complicate somatosensory testing. • Subjects who are in the opinion of the investigator unsuitable for participation in the study. • Subjects with a history of any peripheral or central neuropathy or current chronic pain
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Dr
Annina
Schmid
annina.schmid@ndcn.ox.ac.uk
Dr
Annina
Schmid
annina.schmid@ndcn.ox.ac.uk
Dr
Annina
Schmid
annina.schmid@ndcn.ox.ac.uk
The study is sponsored by University of Oxford and funded by Novo Nordisk A/S; NIHR Oxford Biomedical Research Centre; Wellcome Trust; .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 38454
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
