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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Prof
joris
veltman
joris.veltman@newcastle.ac.uk
Prof
joris
veltman
joris.veltman@newcastle.ac.uk
Diseases of male genital organs
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In approximately half of infertile couples, the cause of the problem is due to a male factor. In more than half of these cases, the aetiology remains undetermined (idiopathic infertility), with no clear cause for the poor sperm quality and/or absence of sperm production. In less than 10% of cases, a genetic origin can be found based on structural or numerical genetic problems such as azoospermia factor (AZF) deletions on the Y-chromosome. Based on the results from twin studies, genetic factors are known to play a major role in male infertility but at the same time we know that this infertility cannot be inherited (except for very rare recessive or polygenic inheritance). This apparent discrepancy of non-heritable genetics can be explained by new, de novo, mutations arising in the germline of the patient. In order to detect these mutations which can occur throughout the genome, we need to study the DNA of infertile men and compare it to the DNA of their parents. This approach has been pioneered very successfully by the lead applicant in Nijmegen, The Netherlands, for intellectual disability and we now want to expand this to severe forms of early-onset male infertility and in this way we expect to identify novel genetic causes of male infertility.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Qualitative;
You can take part if:
You may not be able to take part if:
A potential subject who meets any of the above inclusion criteria will be excluded from participation in this study if there is: • A language barrier to understanding the procedure • No signed informed consent. Participants will be excluded if a known genetic diagnosis is already established as listed in the EAU male fertility guidelines (https://uroweb.org/wp-content/uploads/EAU-Guidelines-Male-Infertility-2016-2.pdf) including obstructive azoospermia (eg. previous vasectomy or congenital absence of vas deferens) or if they have a (non-genetic) identifiable cause for their non-obstructive azoospermia. Other exclusion criteria are: chemo- or radiotherapy for cancer treatment, bilateral orchidectomy, orchitis, retrograde ejaculation or anejaculation.
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by THE NEWCASTLE UPON TYNE HOSPITALS NHS FOUNDATION TRUST and funded by Wellcome Trust .
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Read full details
for Trial ID: CPMS 37706
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