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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Tara
Evans
tn278@cam.ac.uk
Massimiliano
Di Pietro
md460@cam.ac.uk
Massimiliano
Di Pietro
md460@cam.ac.uk
Diseases of oesophagus, stomach and duodenumMalignant neoplasms of digestive organs
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Barrett’s oesophagus (BO) is a metaplastic change in the lining of the oesophagus that predisposes to oesophageal adenocarcinoma. Patients with BO are monitored with a periodic endoscopy and multiple random biopsies (endoscopic surveillance) to detect early neoplastic changes also known as dysplasia. However this practice is highly controversial due to the sampling error inherent in untargeted biopsies. Therefore it is crucial to improve endoscopic visualisation of dysplasia with advanced imaging techniques.
Multispectral imaging represents an exciting new field of investigation in endoscopic research. Multispectral imaging uses a specialised camera to detect multiple colours, allowing us to build a rough spectrum from each point in our image. It is widely reported that these spectra are different for different tissue types, but this is difficult to study ex vivo since de-oxygenation of the blood and decay of the tissue changes these spectra considerably.
We have therefore designed this study to investigate the different multispectral imaging spectra of Barrett's Oesophagus and dysplasia, which we believe might be utilised as a method to detect dysplasia in the future.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Interventional type: Device;
You can take part if:
You may not be able to take part if:
• History of oesophageal stricture precluding passage of the endoscope, • Pregnancy, or planned pregnancy during the course of the study, • Currently breastfeeding • Any history of esophageal varices, liver impairment of moderate or worse severity (Child’s- Pugh class B & C) or evidence of varices on initial treatment endoscopy, • Any history of oesophageal surgery, except for uncomplicated fundoplication, and, • History of coagulopathy, with INR> 1.3 and/or platelet count of < 75,000. On clopidogrel, and/or warfarin for high risk condition and unable to withhold temporarily the medication
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Tara
Evans
tn278@cam.ac.uk
Massimiliano
Di Pietro
md460@cam.ac.uk
Massimiliano
Di Pietro
md460@cam.ac.uk
The study is sponsored by CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST and funded by CANCER RESEARCH UK .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 37630
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