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Other degenerative diseases of the nervous systemOrganic, including symptomatic, mental disorders
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Alzheimer’s Disease (AD) and other types of dementia are caused by changes in the brain. These changes start many years before dementia diagnosis. This means that treatments need to start during the very early stages of illness. One of the first signs of dementia can be when a person perceives that they have memory problems that cannot be detected on neuropsychological test batteries. This is known as Subjective Cognitive Decline (SCD). A related condition is when patients show mild cognitive difficulties that are greater than expected for their age but not severe enough for a diagnosis of dementia. This is known as Mild Cognitive Impairment (MCI). Both SCD and MCI are a strong predictor of dementia as 46% of MCI patients go on to develop dementia within three years of receiving a diagnosis of MCI and up to 60% of people with SCD progress to MCI or AD over a 15-year period. The current project aims to investigate whether the neuropsychological, clinical and neuroimaging profiles of individuals who have SCD/MCI can determine if they will develop dementia. Using a retrospective, longitudinal approach, this study will use already existing and anonymised clinical and neuroimaging data of SCD/MCI patients who were assessed in Essex Memory Clinic between 1994 to present. In order to examine whether the neuropsychological and neuroimaging profiles of SCD/MCI cases that progressed to dementia differ from those that do not decline, patient's demographic information, behavioural measures, physical parameters and performance on a number of neurocognitive tests will be analysed using sophisticated statistical methods, as well as ratings from structural brain scans (CT/MRI). Being able to identify patients at risk of progression to dementia will help clinicians to select patients for effective treatment planning. Treatment at the SCD/MCI stage is a clinical priority as it may delay or possibly prevent progression to dementia.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cohort study;
You can take part if:
You may not be able to take part if:
None
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by University College London and funded by NATIONAL INSTITUTE FOR HEALTH AND CARE RESEARCH .
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for Trial ID: CPMS 37217
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