Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Dr Andrew J Molyneux
+44 (0)1865 234755

Study Location:

Oxford Neurovascular & Neuroradiology Research Unit (ONNRU)

Skip to Main Content
Keep up to date

Sign up for news and information about taking part and shaping research.

International Subarachnoid Aneurysm Trial

Not Recruiting

Open to: All Genders

Age: Adult

Medical Conditions

Neuroscience, psychiatry

This information is provided directly by researchers and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information.

Not provided at time of registration

To compare the safety and efficacy of an endovascular treatment policy of ruptured intracranial aneurysms with a conventional neurosurgical treatment policy in an eligible population.

Primary objective: To determine whether an endovascular treatment policy of acutely ruptured intracranial aneurysms compared with a neurosurgical treatment policy, reduces the proportion of patients with a moderate or poor outcome (defined by Rankin grade 3-6 ) by 25% at one year.

Secondary objectives: To determine if:1. This is as effective as neurosurgery in preventing re-bleeding from the treated aneurysm including long-term follow up2. This results in a better quality of life than neurosurgery at one year (Euroquol measure)3. This is more cost effective than neurosurgical treatment4. This improves the neuropsychological outcome at one year (selected centres only)

Randomised controlled trial

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

01 Jan 1997

31 Dec 2007


2005 Results article in results2010 Results article in results2011 Results article in results2015 Results article in results


Intervention Type : Procedure/Surgery
Intervention Description : 1. Endovascular treatment policy of ruptured intracranial aneurysms2. A conventional neurosurgical treatment policy

You can take part if:

1. Proven subarachnoid haemorrhage (SAH) on Computed Tomography (CT) or lumbar puncture2. Presence of an intracranial aneurysm demonstrated by intra-arterial angiography likely to be responsible for the SAH3. The patient in a clinical state that justifies treatment at some time by either surgical or endovascular means4. Intracranial aneurysm judged to be suitable for either technique based on its angiographic anatomy and the responsible clinician is uncertain which is the best method of treatment5. Appropriate consent of the patient or relatives

You may not be able to take part if:

1. More than 28 days from SAH, unproven SAH2. Unsuitable for both treatments3. Refusal of consent4. Patient participating in another trial

Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Oxford Neurovascular & Neuroradiology Research Unit (ONNRU)
    OX3 9DU

The study is sponsored by Oxford Radcliffe Hospital NHS Trust (UK) and funded by Medical Research Council (MRC) (UK).

We'd like your feedback

Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.

Is this study information helpful?

What will you do next?

Read full details

for Trial ID: ISRCTN49866681

Last updated

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.   

Public Health Agency Northern Ireland
NHS Scotland
Health and Care Rearch Wales