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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Dr
Stephen
Richardson
s.richardson@manchester.ac.uk
Prof
Judith
Hoyland
judith.hoyland@manchester.ac.uk
Other dorsopathies
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The intervertebral disc (IVD) is a strong, fibrous structure which separates, absorbs shock and allow movement between the vertebral bodies of the spine. Back pain is one of the most prevalent and costly socioeconomic disorders affecting the western world today and IVD degeneration represents one of the leading causes of back pain. As the population both grows and ages this problem is increasing. Current medical interventions treat the symptoms, rather than the underlying degeneration and offer poor long-term success, therefore it is essential for new therapies to be developed. Biologic and cell-based therapies offer the potential to regenerate the disc, restore function to the spine and treat back pain. However, for such therapies to be developed it is vital to understand biology of cells within the IVD and to determine the changes which occur during degeneration and the mechanisms behind these changes. We believe that within each region on the IVD, there are different populations of cells, which look similar but behave differently and we aim to develop a detailed understanding of these cells. We also plan to look for biomarkers in blood and IVD tissue which may be used to improve diagnosis and develop more tailored treatments, and to look at clinical images of the degenerate IVD to see whether we can identify degeneration earlier or more precisely. To achieve our aims we will use tissues routinely removed and discarded during surgery. The findings from this research will inform better diagnosis and help direct the development of future therapies for treatment of IVD degeneration and low back pain.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cohort study;
You can take part if:
You may not be able to take part if:
Only adult patients 18 years or older who have capacity to give informed consent will be included in the study. No recruiting of individuals will be conducted for this study.
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Prof
Judith
Hoyland
judith.hoyland@manchester.ac.uk
Dr
Stephen
Richardson
s.richardson@manchester.ac.uk
The study is sponsored by University of Manchester and funded by VERSUS ARTHRITIS; Medical Research Council (MRC); NIHR Central Commissioning Facility (CCF); ROSETREES; .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 35735
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