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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Other forms of heart diseaseDiabetes mellitus
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The number of people with diabetes is rising. One of the major causes of premature death in diabetes is heart failure. This is when the heart cannot pump blood effectively. It makes people feel tired, breathless and develop swollen limbs. It is associated with a high risk of dying. The prevalence and causes of heart failure in diabetes are uncertain. A key process may be build up of fat in the heart, stopping it from filling and pumping as it should. We will undertake a thorough assessment of heart structure and function, initially in 150 people with type 2 diabetes who have no signs of heart failure. All subjects will have an MRI, CT, ultrasound scan of the heart, exercise and blood tests. We will use medical records to see how many people in the study develop heart health problems over the next five years. We will perform the same tests in 50 people without diabetes, as a comparison. This will reveal how frequently and which abnormalities occur early on in the diabetic heart, and the best way of predicting them. It will help us understand diabetic heart disease and which aspects may be targeted with new treatments.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cross-sectional;
You can take part if:
You may not be able to take part if:
Patients: • Angina pectoris or limiting dyspnoea (> NYHA II). • Major atherosclerotic disease: Symptomatic coronary artery disease (CAD), history of myocardial infarction, previous revascularisation, stroke/transient ischaemic attack or symptomatic peripheral vascular disease. • Atrial fibrillation or flutter. • Moderate or severe valvular heart disease. • History of heart failure or cardiomyopathy. • Type 1 diabetes mellitus (T1DM). • Low fasting C-peptide levels suggestive of adult-onset T1DM. • Stage III-V renal disease (estimated glomerular filtration rate < = 30ml/min/1.73m2). • Absolute contraindications to cardiac MRI. Controls: As for patients and additionally: • diabetes or impaired glucose tolerance. • Uncontrolled hypertension (BP> 160/100 mmHg) • Other conditions that in the opinion of the investigators may limit exercise capacity or be associated with subclinical cardiac dysfunction.
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by University of Leicester and funded by BRITISH HEART FOUNDATION .
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Read full details
for Trial ID: CPMS 34795
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