We'd like your feedback
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Other diseases of intestinesMalignant neoplasms of digestive organs
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
Colorectal cancer (CRC) is the 2nd commonest cause of cancer death in the UK. Survival rates are among the lowest in Europe yet if diagnosed early, exceed 90%. A breath test is a non-invasive investigation, detecting the presence of volatile organic compounds (VOCs) in breath and their alteration in colorectal cancer. The use of a breath test in Primary Care could identify high-risk patients who should be referred for colonoscopy at an earlier stage, increase the proportion of appropriate referrals, and improve NICE guidelines. It could also provide reassurance to patients who do not have cancer, and prevent unnecessary endoscopies in this group. It could also have an application for colorectal cancer screening.
We propose to determine the diagnostic accuracy of the exhaled breath test for the prediction of colorectal cancer and colonic polyps. This will also involve testing VOCs in urine and colonic air so as to understand the mechanism of VOC production and excretion in humans.
In order to determine the accuracy of the breath test we propose to sample the breath and urine of 2000 patients attending for endoscopy or attending a secondary care consultation over multiple hospitals around London. Patients will be asked to breathe into a breath sampling device, which will take 5-10 minutes. The VOCs in breath are absorbed onto adsorbent tubes, which are then sent to the laboratory for analysis by mass spectrometry. Identify and quantity of VOCs can then be compared in patients with normal colons, benign diseases of the colon, colonic polyps and CRC. Colonic air samples and urine samples will also be analysed using mass spectrometry.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Interventional type: Device;
You can take part if:
You may not be able to take part if:
• Lacks capacity or is unable to provide informed consent. • Any patient below 18 years of age or over 90 years of age
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by Imperial College of Science, Technology and Medicine and funded by ROSETREES .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 34018
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
