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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Julie
Foster
Julie.Foster@gstt.nhs.uk
Prof
Catherine
Williamson
catherine.williamson@kcl.ac.uk
Diseases of liverPersons encountering health services in circumstances related to reproduction
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For some years we have known that the health of fathers at the time a baby is conceived has an influence on the health of their children. Many of the studies looking at this effect have investigated fathers with obesity and other metabolic disorders. These disorders are associated with an increased risk of heart disease and diabetes in the children. More recently, studies have been undertaken to establish the mechanism by which this risk is inherited by the children. Studies of sperm have identified that changes in the structure and function of the sperm play a role.
Our group is interested in cholestatic liver diseases, which are a group of conditions characterised by elevated levels of bile acids in the blood. We are also interested in the long-term effects of elevated levels of bile acids. We have recently established that children born to women who have cholestasis during pregnancy are at an increased risk of obesity later in life. We would now like to investigate whether there is a similar effect on the health of children if their father has cholestasis.
Our study has two arms. Firstly, we will investigate the structure and function of sperm from men with cholestasis and compare this to the structure and function of sperm from healthy men (Sperm Epigenome Study). Secondly, we will evaluate the health of the adolescent / young adult children of men who had cholestasis at the time of conception and compare this to the health of adolescent / young adult children born to men who were healthy at the time of conception (Outcomes Study).
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Case-controlled study;
You can take part if:
You may not be able to take part if:
Sperm Epigenome Study: Cholestatic Men: •Men with a history of diabetes or obesity. •Men with gallstones, cancer or other acute cholestatic pathology. •Men with a history of alcohol excess or drug abuse. •Men who smoke. •Men with blood-borne viruses e.g. HIV and hepatitis. •Men who are unable or unwilling to give informed consent. Healthy Control Men: •Men with a history of cholestasis or liver disease. •Men with a history of diabetes or obesity. •Men with a history of alcohol excess or drug-abuse. •Men who smoke. •Men with blood-borne viruses e.g. HIV and hepatitis. •Men undergoing fertility treatment due to male factor. •Men unable or unwilling to give informed consent. Outcomes Study: Cholestatic Father-Adolescent/Young Adult Child Pairs: Fathers: •Cholestatic fathers with a history of diabetes or obesity at the time of conception of their child. •Cholestatic fathers with a history of alcohol excess or drug-abuse at the time of conception of their child. •Cholestatic fathers who smoked at the time of conception of their child. •Cholestatic fathers with blood-borne viruses e.g. HIV and hepatitis at the time of conception of their child. Adolescent/young adult children: •Adolescent/young adult children who were born as a result of multi-fetal pregnancy. •Adolescent/young adult children with a history of alcohol excess or drug-abuse. •Adolescent/young adult children who are ≤16 years of age, or ≥ 25 years of age. •Adolescent/young adult children with blood-borne viruses e.g. HIV and hepatitis. •Adolescent/young adult children who are unable or unwilling to give informed consent.
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by King's College London and funded by PSC SUPPORT .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 33406
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