We'd like your feedback
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Paresh
Malhotra
p.malhotra@imperial.ac.uk
Paresh
Malhotra
p.malhotra@imperial.ac.uk
Cerebrovascular diseases
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
Brain injury, such as stroke, very commonly results in long-term cognitive problems such as poor concentration or
memory deficits. Altough these problems have devastating effects on patients' lives, only a limited number of
treatments have proven to be effective.
In healthy brains, cognitive tasks involve different brain regions that are connected to each other in networks. Patients
with brain injury have damage to the grey and white matter, i.e., the functional 'hubs' and the 'wires' in the brain, which
are responsible for their long-term cognitive deficits.
Non-invasive transcranial electrical stimulation (TES) of the brain has been shown to succesfully improve motor
functions following stroke. Recent research has provided more information on how TES works, helping us to better
understand how to design effective TES paradigms to aid motor recovery after stroke. The same approach can be
used for TES studies in the cognitive field, since TES has been shown great potential in modulating cognitive function
in both healthy and brain-injured participants.
Here, we propose to investigate the effect of TES on cognitive functions (e.g., attention, language etc.) and brain
network activity in healthy and neurological conditions. Cognitive functions will be tested using established
neuropsychological assessment, which includes paper-based and computerised tests. In some cases, magnetic
resonance imaging (MRI) and electroencephalography (EEG) will be used to investigate changes in brain activity
induced by TES.
This research will greatly enhance our understanding of TES as a potential tool for improving cognitive functions
following stroke.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Type: Imaging;Rehabilitation;
You can take part if:
You may not be able to take part if:
Exclusion Criteria for ALL participants: 1) Inability to follow instructions or complete tasks pertaining to the experiment as a result of severe cognitive deficits or language barriers 2) Inability to give informed consent (see section 8 in the protocol) 3) Major co-morbid conditions or pregnancy* 4) Severe scalp skin lesions, metal implants in the upper part of body 5) Likely to stop or start any psychoactive medications during the course of their participation in the study (i.e. antidepressants, neuroleptics 6) Active epilepsy 7) Contraindications (e.g., claustrophobia, any metallic object in the body etc.) to MRI scanning**
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by Imperial College of Science, Technology and Medicine and funded by Wellcome Trust .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 32365
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
