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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Dr
Richard
Day
r.m.day@ucl.ac.uk
Prof
Charles
Knowles
c.knowles@ucl.ac.uk
Prof
Charles
Knowles
c.knowles@ucl.ac.uk
william
english
william.english.22@ucl.ac.uk
Other diseases of intestines
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
Perianal fistulas are a connection between the anal canal and the skin surface creating an abnormal passageway for the discharge of bodily fluids. The goals of fistula treatment are to close the fistula after removing material from within that might cause infection, whilst trying to avoid damage to the surrounding tissue that could cause incontinence. A range of materials have been used to fill fistulas in an attempt to promote healing but many of these have failed because the material becomes dislodged and falls out or results in an infection. The use of highly porous microspheres might overcome this problem. When packed into a fistula the microspheres should provide a ‘scaffold’ that cells can easily grow between and into. As the microspheres slowly dissolve they are replaced by new tissue. As a first in man feasibility study, the aim of this clinical trial is to demonstrate that the microspheres are safe when implanted into perianal fistulas in humans.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Interventional type: Device;Imaging;Management of Care;Surgery;Active Monitoring;
You can take part if:
You may not be able to take part if:
Secondary fistula, including Crohn’s disease, carcinoma, radiotherapy, tuberculosis Evidence of branching fistula anatomy or cavity on MRI Intersphincteric fistula Previous fistula surgery Immunosuppressed patients Participants less than 18 years of age Unwilling to consent Pregnancy or Breastfeeding Known allergy to PGLA
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Prof
Charles
Knowles
c.knowles@ucl.ac.uk
william
english
william.english.22@ucl.ac.uk
Prof
Charles
Knowles
c.knowles@ucl.ac.uk
Dr
Richard
Day
r.m.day@ucl.ac.uk
The study is sponsored by University College London and funded by Wellcome Trust .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 32128
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
