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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Disorders of optic nerve and visual pathwaysExtrapyramidal and movement disordersSymptoms and signs involving cognition, perception, emotional state and behaviour
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Parkinson’s disease is a common neurodegenerative disease. As well as the recognised effects on movements,
patients suffer from visual disturbance, even at the earliest stages. Later in the disease, visual symptoms such as
hallucinations are extremely distressing to patients and their carers. There are no effective treatments and little is
known about how and where visual processing breaks down in Parkinson’s disease, or why some patients with
Parkinson’s disease are more prone to visual symptoms than others.
This study is a cross sectional and longitudinal study of patients at different stages of Parkinson’s disease, ranging
from presymptomatic, through early stages to advanced Parkinson’s disease. We will examine different forms of
Parkinson’s disease, including patients carrying genetic mutations associated with Parkinson’s disease and those
with cognitive impairment.
Study participants will undergo psychology testing, a blood test and perform computerÂ-based visual and auditory tasks.
Some of these tasks will be performed whilst undergoing brain imaging. This will allow us to measure performance in
visual processing tasks whilst examining brain responses. By combining behavioural measures of visual processing
with underlying measures of brain responses in genetically and clinically defined patient groups, we can determine
those aspects of visual processing that are damaged in different forms of Parkinson’s Disease. Patients will be
assessed at baseline and then invited back for reassessment after one year.
The first stages of this project will involve pilot testing computerised visual and auditory tasks in patients and healthy
controls.
The key objectives are to identify the brain regions associated with visual dysfunction in different forms of Parkinson’s
Disease and to determine if these can be detected at the earliest stages of the disease process.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cohort study;
You can take part if:
You may not be able to take part if:
General exclusion criteria 1. Participant has another medical or psychiatric illness that would interfere in completing assessments or impair the safety of the subject. MRI exclusion criteria 1. Pacemaker 2. Surgical Aneurysm clips 3. Implanted metal prosthesis 4. Implanted pumps There are no exclusionary medications for this study.
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by University College London and funded by L'OREAL; University College London; Wellcome Trust; .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 20383
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
