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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Prof
Anna
David
a.david@ucl.ac.uk
Miriam
Bourke
miriam.bourke@nhs.net
Vanessa
Greening
vanessa.greening@nhs.net
Sarah
Weist
sarah.weist@nhs.net
Prof
Anna
David
a.david@ucl.ac.uk
Justin
Willenborg
j.willenborg@nhs.net
Maternal care related to the fetus and amniotic cavity and possible delivery problems
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
Guided Instrumentation for Fetal Therapy and Surgery is a sevenÂyear project funded by the Wellcome Trust and Engineering and Physical Sciences Research Council (EPSRC). In collaboration with KU Leuven, Great Ormond Street Hospital and University College Hospital (UCLH) we aim to develop lowÂrisk techniques for diagnosis and treatment of a range of debilitating abnormalities of the baby during pregnancy and before birth. This will have significant impact as at present around 1% of babies are born with severe defects, and these are collectively responsible for over a third of all paediatric hospital admissions. Early prenatal intervention in some types of congenital disease can reduce disease morbidity. For example open fetal surgery to correct myelomeningocoele (spina bifida) during pregnancy reduces the postnatal requirement for ventricular shunts and improves motor function in affected neonates. The provision of more and better preÂoperative data to surgeons allows them to optimally prepare for surgery, and is usually provided by fetal magnetic resonance imaging (MRI). Currently fetal MRI is limited by difficulties with image acquisition due to fetal movements, and a lack of knowledge about the best sequences to use. We wish to improve fetal MRI, currently used for prenatal diagnosis and monitoring of fetal outcome after prenatal treatment.
The research study will ask women who are undergoing fetal MRI for prenatal diagnosis, if they would agree to allow us to perform extra MRI imaging up to a certain time limit, for research purposes. We will also invite women who do not need fetal MRI for prenatal diagnosis whether they would agree to undergo imaging for research purposes. Using the extra MRI time we will be able to image parts of the fetus that are not being studied for clinical purposes, and develop different types of sequences to improve the fetal images that we can acquire.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cohort study;
You can take part if:
You may not be able to take part if:
Anyone under the age of 18 years. Anyone unable to give informed consent to additional imaging. Anyone with a contraÂindication to MRI (eg metal implants)
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Miriam
Bourke
miriam.bourke@nhs.net
Vanessa
Greening
vanessa.greening@nhs.net
Sarah
Weist
sarah.weist@nhs.net
Justin
Willenborg
j.willenborg@nhs.net
Prof
Anna
David
a.david@ucl.ac.uk
Prof
Anna
David
a.david@ucl.ac.uk
The study is sponsored by University College London and funded by Engineering and Physical Sciences Research Council (EPSRC); Wellcome Trust; .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 20210
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
