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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Miss
Sheena
Thomas
sheena.thomas@cardiov.ox.ac.uk
Dr
Charalambos
Antoniades
antoniad@well.ox.ac.uk
Maria
Lyasheva
maria.lyasheva@cardiov.ox.ac.uk
Alina
Florea
alina.florea@cardiov.ox.ac.uk
Cerebrovascular diseasesIschaemic heart diseasesOther forms of heart disease
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
This is a single centre, prospective cohort observational study involving patients undergoing computed tomography angiography (CTA), and
patients attending outpatient clinics at the Oxford University Hospitals
(OUH) NHS Trust. A total of 2500 participants will be consented to
search for biomarkers in the blood that might be able to predict the risk of future cardiovascular events such as heart attack or
stroke and to identify novel biomarkers which are able to predict
vascular disease pathogenesis and the extent of preÂ-existing vascular disease.
Upon consenting to take part in the study, a sample of blood will be
taken from the participants and they will be asked to consent to: their medical records to be accessed annually; conduct a brief telephone
questionnaire every two years; the use of clinical images obtained for
clinical purposes to perform measurements of imaging biomarkers of
metabolic risk and assess the severity of vascular and cardiac disease; have anthropometric measurements taken during their clinical visit that includes height, weight, and waistÂ-hipÂ-ratio.
Those undergoing a CTA will also be asked to consent to a follow up CTA approximately 3 years later to assess for any cardio-vascular disease progression.
At the end of the study, nested caseÂcontrol studies will be undertaken. A unique cohort of participants will
have been created that will allow the potential for subgroups to be formed and called back for future studies. Exploratory data analysis will be
performed for all variables derived from this study to obtain the
appropriate summary statistics. Where necessary, transformation of
data will be performed for further statistical testing. Between patient
relationships of plasma/imaging biomarkers will be assessed using
appropriate hierarchical or multilevel data analysis.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cohort study;
You can take part if:
You may not be able to take part if:
The participant is unable or unwilling to consent. The participant has active cancer. For study Arm 1:Â A total of 500 participants attending Cardiology Department, Hypertension or University outpatient clinics at the Oxford University Hospitals (OUH) NHS Trust will be enrolled to the study For Study Arm 2:Â A total of 1000 participants undergoing CT Angiography for clinical reasons or as part of other research studies within the radiology departments of the OUH NHS Trust will be included in the study. For Study Arm 3:ÂA total of up to 1000 OUH NHS Trust patients, who over the past 5 years have had a Coronary CTA scan (e.g. as part of their clinical care), will be the potential candidates for this study arm.
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Alina
Florea
alina.florea@cardiov.ox.ac.uk
Dr
Charalambos
Antoniades
antoniad@well.ox.ac.uk
Miss
Sheena
Thomas
sheena.thomas@cardiov.ox.ac.uk
Maria
Lyasheva
maria.lyasheva@cardiov.ox.ac.uk
The study is sponsored by University of Oxford and funded by NIHR Oxford Biomedical Research Centre .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 20049
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
