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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Prof
Sue
Kimber
sue.kimber@manchester.ac.uk
Prof
Sue
Kimber
sue.kimber@manchester.ac.uk
Arthrosis
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This is a study of osteoarthritis using tissue from patients knee joints removed at surgery for joint replacement. Patients with osteoarthritis will be asked to donate tissue and to provide a blood and urine sample for the study. Age matched patients without osteoarthritis, but who require limb amputation for other medical reasons, will also be asked to donate tissue, blood and urine for the study. This will provide important non-osteoarthritic samples for comparison in the study. Samples of tissue and cells from the OA and non-OA patients will be isolated for a range of analysis and live cells will also be grown in culture and tested. The main focus is on cartilage tissue and the chondrocytes, the live cells in cartilage. In addition cells from patients tissues, from urine and from blood, will be converted using gene transfer into stem cells (induced pluripotent stem cells) for further research into what makes cartilage become osteoarthritic. These studies require detailed comparison between OA and non-OA patients and combining the results from these different research approaches using the latest systems biology methods will provide a comprehensive analysis of osteoarthritis and it will identify many possible new routes to treatment.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Clinical Laboratory Study;
You can take part if:
You may not be able to take part if:
OA Group: Patients for knee replacement with any nonosteoarthritis joint pathology, such as rheumatoid arthritis. Non-OA Controls: Patients requiring limb amputation, who have any joint pathology.
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by University of Manchester and funded by VERSUS ARTHRITIS; European Commission; Medical Research Council (MRC); .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 15541
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
