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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Mr
George
Saleh
george.saleh@moorfields.nhs.uk
Melanie
Ekani
melanie.ekani1@nhs.net
Disorders of eyelid, lacrimal system and orbit
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In this work we shall be investigating the transdermal properties of nanoparticle carriers and their active agents on eyelid skin.
Potential donors will be identified by NHS clinicians on site. These patients will be attending for blepharoplasty, blepharoptosis or other excess skin-tissue removal. The patients will be approached and, if agreeable, consented to the use of this excess tissue to be used in laboratory research as opposed to being disposed directly.
Tissue will be collected by a research student and transported directly in a polystyrene ice box to University of Hertfordshire (UH) in an anonymised fashion. All skin is assigned a unique code on arrival at UH to allow later identification of the samples. The consent forms are retained by the NHS site and should the donor withdraw consent the NHS site can contact UH with the details listed above and the skin sample can be destroyed at the request of the donor.
The work conducted will focus on researching new and existing topical medical products for improving treatment to the eyelid area. Currently eyelid surgery/treatment typically requires injections of drugs/anaesthesia to the eyelid skin area.
This is a painful procedure with potential risk of complications and hence poor patient compliance. The alternative method is to apply the treatment or anaesthesia locally in the form of cream, suspension, solution or lotion. However, to date systematic investigations of how these different types of formulations affecting the drug penetration across the eyelid is not known. Additionally new formulations which utilise nanotechnology might increase the drug penetration across the eyelid and these formulations have not been systematically evaluated as well. Therefore, the research conducted will examine the drug penetration from existing or nanoparticle formulations based on an in vitro model using excised eyelid skin.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Clinical Laboratory Study;
You can take part if:
You may not be able to take part if:
Any patient not already attending for excess eyelid and surrounding tissue removal or patients who do not wish to participate.
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by MOORFIELDS EYE HOSPITAL NHS FOUNDATION TRUST and funded by Engineering and Physical Sciences Research Council (EPSRC) .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 14346
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