Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Mrs Reem Al-Saadi
Reem.Al-Saadi@ucl.ac.uk


Dr Tanzina Chowdhury
Tanzina.Chowdhury@gosh.nhs.uk


Prof Kathryn Pritchard-Jones
Reem.Al-Saadi@ucl.ac.uk


Study Location:

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Be Part of Research - Trial Details - UMBRELLA. A SIOP Renal Tumours Study Group prospective clinical study

UMBRELLA. A SIOP Renal Tumours Study Group prospective clinical study

Medical Conditions

Malignant neoplasms of urinary tract


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This project aims to improve short and long term outcomes for children and young people with Wilms (WT) and other childhood renal tumours through the introduction of a more ‘personalised’ approach to risk stratification. This will include biological characterisation of tumour, blood and urine samples to better define the molecular pathways involved, particularly in high risk, ‘blastemal type’ Wilms tumour. There will be central review of tumour pathology and of any imaging studies (scans) performed in ‘real time’, to test the feasibility of integrating all of these complex datasets within a newly developed e-health tool project known as “P-medicine”, that will be used to improve clinical decision making in a future clinical trial.

Each patient’s treatment will be according to the currently accepted best practice, that is based on the recently closed phase III clinical trial run by the International Society of Paediatric Oncology (SIOP) Renal Tumours Study Group, in which the UK was a major participant.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

19 Sep 2012 31 Jan 2028

Observational

Observational type: Clinical Laboratory Study;



You can take part if:



You may not be able to take part if:


Patients who do not give/whose parents do not give consent for inclusion of their clinical/imaging or biological sample data. (note that patients/parents can consent separately to the biological studies so may still be registered if they consent for inclusion of their clinical/imaging data but will be excluded from the biological studies if they so wish).


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Cardiff & Vale University Lhb
    Woodland House
    maes-y-coed Road
    Cardiff
    CF14 4HH
  • Great Ormond Street Hospital Central London Site
    Great Ormond Street
    London
    Greater London
    WC1N 3JH
  • Leicester Royal Infirmary
    Infirmary Square
    Leicester
    Leicestershire
    LE1 5WW
  • Sheffield Children's Hospital
    Western Bank
    Sheffield
    South Yorkshire
    S10 2TH
  • The Royal Victoria Infirmary
    Queen Victoria Road
    Newcastle Upon Tyne
    Tyne And Wear
    NE1 4LP
  • The Royal Marsden Hospital (surrey)
    Downs Road
    Sutton
    Surrey
    SM2 5PT
  • Southampton General Hospital
    Tremona Road
    Southampton
    Hampshire
    SO16 6YD
  • Addenbrooke's Hospital
    Hills Road
    Cambridge
    Cambridgeshire
    CB2 0QQ
  • Birmingham Children's Hospital
    Steelhouse Lane
    Birmingham
    West Midlands
    B4 6NH
  • Clarendon Wing, Leeds General Infirmary
    Belmont Grove
    Leeds
    West Yorkshire
    LS2 9NS
  • Nottingham University Hospitals NHS Trust - Queen's Medical Centre Campus
    Nottingham University Hospital
    derby Road
    Nottingham
    Nottinghamshire
    NG7 2UH
  • John Radcliffe Hospital
    Headley Way
    headington
    Oxford
    Oxfordshire
    OX3 9DU
  • Alder Hey Children's NHS Foundation Trust
    Alder Hey Hospital
    eaton Road
    west Derby
    Liverpool
    Merseyside
    L12 2AP
  • Bristol Royal Hospital For Children
    Upper Maudlin Street
    Bristol
    BS2 8BJ
  • Royal Hospital For Sick Children (glasgow)
    1345 Govan Road
    Glasgow
    G51 4TF
  • Royal Manchester Children's Hospital
    Oxford Road
    Manchester
    Greater Manchester
    M13 9WL
  • Royal Aberdeen Children's Hospital
    Westburn Drive
    Aberdeen
    AB25 2ZG
  • Royal Hospital For Sick Children (edinburgh)
    9 Sciennes Road
    Edinburgh
    Lothian
    EH9 1LF

Mrs Reem Al-Saadi
Reem.Al-Saadi@ucl.ac.uk


Dr Tanzina Chowdhury
Tanzina.Chowdhury@gosh.nhs.uk


Prof Kathryn Pritchard-Jones
Reem.Al-Saadi@ucl.ac.uk



The study is sponsored by GREAT ORMOND STREET HOSPITAL FOR CHILDREN NHS FOUNDATION TRUST and funded by CANCER RESEARCH UK .




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for Trial ID: CPMS 12457

Last updated 10 March 2025

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