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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Disorders of ocular muscles, binocular movement, accommodation and refractionDisorders of optic nerve and visual pathwaysOther disorders of eye and adnexa
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Genes are found in the cells of our body and are the instructions that tell our body how to grow and develop. The DNA sequence that makes up our genes is remarkably similar from one person to the next, but tiny variations do occur, making each of us a unique individual. Most of these changes in our genes are harmless. However, there can be changes that cause them not to work properly and lead to health problems or disease. We wish to determine and understand which genes are important for brain development by studying the changes in genes of individuals who have disorders affecting their eye movement, cranial nerve abnormalities (nerves at the back of the brain which control how the eyes move or optic nerves) and their associated anomalies. We hope that the knowledge we gain from this research will lead to improved diagnosis, management and treatment of these conditions.
We hope to recruit patients who present with complex or common strabismus or associated anomaly i.e. nystagmus and their unaffected and affected family members. Recruited participants will undergo an eye examination and be asked about they medical and family history. We may also record eye movements using videotapes, infrared video cameras and/or photography. We may also use drops to dilate participant’s pupils so we can take photographs of the back of the eye or alternatively using a scanning light with equipment called optical coherence tomography. We will also take a DNA sample from each participant most often we will take a saliva sample but if this cannot be provided a blood sample or swab may be used. DNA will be used to perform linkage analysis which will help to locate abnormal changes within the gene.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Genetic epidemiology;
You can take part if:
You may not be able to take part if:
•Strabismus secondary to certain known risk factors, including brain tumour, cerebral palsy, juvenile rheumatoid arthritis, sickle cell disease or other blood disease, trisomy 21, hydrocephalus, and s/p stroke. •Not having such a diagnosis and not being related to such an individual •Not wishing to participate •Being incapable of giving consent and not having a legal guardian willing or able to do so.
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by University of Leicester and funded by National Institutes of Health (NIH), United States .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 11854
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
