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Contact Information:

Study Location:

University of Nottingham
Nottingham


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Specialist Recommendation on FBC (Familial Breast Cancer) Chemoprevention Prescribing

Not Recruiting

Open to: All Genders

Age: All

Medical Conditions

Familial Breast Cancer


This information is provided directly by researchers and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information.




Some women are more likely to get breast cancer as it runs in their family, they are at risk of familial breast cancer. There are medications, called chemoprevention, which may lower their risk of developing breast cancer by a third. However chemoprevention can also cause serious side effects, like womb cancer and blood clots. This makes decision to start them difficult. Researchers found that not all women who can have these medications are on them. The investigators want to ask familial breast cancer specialists whether they recommend general practitioners (GP) to prescribe chemoprevention, by sending them a short survey. These specialists look after women where breast cancer runs in the family. The specialists assess a women's chance of getting breast cancer and advice those with increased risk what can be done to prevent breast cancer. The investigators will then look at whether specialist recommendation makes a difference to whether GPs prescribe chemoprevention medication. This will be done by linking the specialists' survey response to information on GP prescribing that the government regularly publishes. This may help the investigators understand why chemoprevention is not used as often as it potentially can be.

Phase I: Short survey of lead clinicians of familial cancer services, descriptive analysis of recommendations by areas of the country Phase II: Prescribing data analysis (using OpenPrescribing) comprising: 1. t-test to compare the chemoprevention prescribing rate in general practices where chemoprevention is recommended versus not recommended; 2. interrupted times series analysis to assess the change in the chemoprevention prescribing after recommendation from specialist compared with changes occurring in practices where chemoprevention is not recommended and 3. panel regression across all practices, in order to distinguish the relative impacts of national versus local recommendation, and the change over time.


Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jul 2019

Dec 2021

Observational

Intervention Type : Other
Intervention Description : Completion of a short survey.

Intervention Arm Group : Familial breast cancer risk assessment services in England

You can take part if:


Inclusion Criteria: - Lead clinicians of NHS familial cancer services across England - Standard general practices (classed as type 4 by NHS Digital, to exclude walk-in centres, prisons, care homes, etc.) with prescribing data for chemoprevention available on OpenPrescribing Exclusion Criteria: - General practices with less than 10 female patients aged 35 to 44 registered - General practices which cannot be linked to any familial cancer service from survey responses




You may not be able to take part if:

This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • University of Nottingham
    Nottingham


The study is sponsored by University of Nottingham and funded by University of Oxford .



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for Trial ID: NCT04058418

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