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Dr Alexandre Loktionov


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Be Part of Research - Trial Details - Cancer detection by analysing non-invasively collected colorectal mucus
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Cancer detection by analysing non-invasively collected colorectal mucus

Not Recruiting

Open to: All Genders

Age: Adult

London Cambridge

Medical Conditions

Colorectal cancer

This information is provided directly by researchers and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information.


Colorectal cancer (CRC), also known as bowel cancer, is the third most common cancer. It is a global healthcare problem, causing almost 700,000 deaths worldwide every year. This disease usually affects people over the age of 50 and does not produce symptoms at its early stages. Very often CRC is detected too late to be successfully treated. Early detection of this cancer, especially through population screening, saves lives, but the existing tests used for this purpose are not sensitive enough or too expensive. DiagNodus Ltd has recently developed a new technique for collecting samples of colorectal mucus which can be used to measure the levels of chemicals called biomarkers and detect inflammatory bowel disease (IBD). As it is well known that CRC also produces dramatic changes in colorectal mucus, it is highly likely that CRC biomarkers can be found in this material as well. The aim of this study is to examine if the new approach devised by DiagNodus Ltd is suitable for detecting CRC.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

15 Jan 2017 30 Sep 2019

Publications

2020 Results article in https://pubmed.ncbi.nlm.nih.gov/32398859/ (added 01/12/2022)

Participants have their diagnoses confirmed by colonoscopy, a test where the doctor looks at the inner lining of the colon using a thin, flexible tube. Participants are then provided with a kit for sample collection and are instructed to collect two samples of colorectal mucus 3-5 days after colonoscopy (CRC patients usually have surgery at least two weeks after colonoscopy). Sample collection is performed by the participants at home. Once samples are collected, they are sent to the laboratory of DiagNodus Ltd, where all planned laboratory tests are carried out. The results of the tests are matched to diagnostic information (colonoscopy) at the end of the study.


Patients aged over 45 with confirmed colorectal cancer, and tumour-free patients for comparison

You can take part if:



You may not be able to take part if:


1. Age below 452. The presence of active gastrointestinal diseases or major gastrointestinal surgery in the past3. Ongoing treatment with hormonal, immunosuppresive or cytostatic drugs


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • St George's Hospital
    Blackshaw Rd
    London
    SW17 0QT
  • DiagNodus Ltd
    Bldg 280 Babraham Research Campus
    Cambridge
    CB22 3AT

Although patients are unlikely to benefit from participating, the results of the study are likely to provide significant benefits for patients and medical professionals in terms of developing a new approach to CRC early detection and screening. The eventual goal is to provide a simple, highly sensitive and affordable test for CRC screening. Providing samples does not interfere with routine treatment. Sample collection is safe and very well accepted by patients. For these reasons no potential risks of participating in the study can be identified.

Dr Alexandre Loktionov



The study is sponsored by DiagNodus Ltd and funded by DiagNodus Ltd.



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Read full details for Trial ID: ISRCTN16782445
Last updated 01 December 2022

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