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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Prof Michael Trenell
+44 (0)191 248 1150
m.i.trenell@ncl.ac.uk


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Be Part of Research - Trial Details - High Intensity Exercise Training in Type 2 Diabetes
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High Intensity Exercise Training in Type 2 Diabetes

Not Recruiting

Open to: All Genders

Age: Adult

Newcastle Upon Tyne

Medical Conditions

Type 2 Diabetes

This information is provided directly by researchers and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information.


Recent information suggests that exercise may help people with type 2 diabetes improve their glucose control by increasing the ability of the body to burn fat, and increasing the sensitivity of the body to food. We aim to show the effect of exercise on sensitivity of the body to food, levels of fat in the liver and abdomen, and heart function.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

01 Sep 2012 30 Sep 2013

Publications

2015 Results article in http://www.ncbi.nlm.nih.gov/pubmed/26265792 results2016 Results article in http://www.ncbi.nlm.nih.gov/pubmed/26350611 results2019 Results article in http://www.ncbi.nlm.nih.gov/pubmed/30541346 results (added 15/03/2019)

You will be assigned to one of two groups. The first group will do three exercise sessions per week over 12 weeks. Each exercise session will involve you using a stationary cycle and resistance band, and will last about 40 minutes. A member of the research team will come with you on your first session to familiarise you with doing the exercises safely and after that an ipod with exercise tracks will guide you through the remaining sessions. Exercise will be held at a local gym which you choose and your gym membership will be paid for during the study. To maintain your weight throughout the study you will be given high calorie food supplements if your weight goes down by more than 1%. The second group will not do the exercise sessions or be required to undertake any exercise over the 12 weeks. If you are placed in this group, at the end of the study you will be given the opportunity to receive the exercise training, though this is not compulsory. Both groups will attend the Newcastle Magnetic Resonance Centre at the Newcastle General Hospital, or the Royal Victoria Infirmary on 5-9 occasions over 3 months. These visits include fasting blood tests, exercise tests, magnetic resonance scans and body composition measurements. You will wear a small device on your upper arm for 7 consecutive days before the 12 weeks and at the end to measure physical activity levels.


Men and Women aged between 30-70 years with Type 2 Diabetes, have a body mass index (BMI) between 25-35kg/m2 and who currently take part in no regular exercise.

You can take part if:



You may not be able to take part if:


1. The absolute and relative contraindications to exercise testing as stated by the American Heart Association (Fletcher et al., 2001)2. Taking insulin/Sulfonylurea/ TZD/ Beta-blockers3. Contraindications for MRI scanning4. Heart or kidney disease5. Undergoing dietary change


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Newcastle Univeristy
    Newcastle Upon Tyne
    NE3 5JB

Being more physically active may be beneficial to the level of fat in your liver and if sustained after the study, may help in preventing other complications such as heart disease. You will have supervised exercise sessions which will teach you about your body, show you how to exercise correctly and help you become more physically fit. This study involves exercise so there are no side effects. Disadvantages of the study could be the time given up to participate and some people can experience claustrophobia (fear of confined spaces) in the magnetic resonance scan but if this happens we immediately stop the scan.

Prof Michael Trenell
+44 (0)191 248 1150
m.i.trenell@ncl.ac.uk



The study is sponsored by Newcastle upon Tyne Hospitals NHS Foundation Trust (UK) and funded by National Institute for Health Research (UK) - Biomedical Research Centre for Ageing and Age Related Diseases.



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Read full details for Trial ID: ISRCTN78698481
Last updated 15 March 2019

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