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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Prof
Deb
Pal
Miss
Holly
Crudgington
+44 (0)20 7848 5162
Holly.crudgington@kcl.ac.uk
More information about this study, what is involved and how to take part can be found on the study website.
People with a diagnosis of Juvenile Myoclonic Epilepsy
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
Epilepsy is a common neurological disorder affecting 1% of the population. There are over 30 types of epilepsy, some common, some rare. Most epilepsies arise in childhood and have a genetic cause. Approximately 40% of patients have the common forms of Genetic Generalised Epilepsy (GGE), and the commonest GGE is “Juvenile Myoclonic Epilepsy” or JME. There is overwhelming evidence that JME is caused by changes in genetic code. These changes are likely to be found in more than just one gene and there may be more than one type of change. In order to find these changes we need to study a large number of people with JME and compare their genetic code with people who do not have epilepsy. Finding the causes of JME will lead to a better understanding of its cause, new treatments, and tailoring of treatments according to a person's genetic make-up. The aim of this study is to find the genetic cause for JME by comparing the genetic code in JME patients with that in people who do not have epilepsy, using clues from their electroencephalograph or brainwave test that is used to help diagnose epilepsy.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
You can take part if:
Current inclusion criteria as of 08/05/2025:
1. Diagnosis of Juvenile Myoclonic Epilepsy in accordance with Consensus criteria
2. Age of myoclonus onset 6-25 years
3. Seizures comprising predominant or exclusive early morning myoclonus of upper extremities
4. EEG interictal generalized spikes and/or polyspike and waves with normal background
5. Current a
You may not be able to take part if:
1. Myoclonus only associated with carbamazepine or lamotrigine therapy2. EEG showing predominant focal interictal epileptiform discharges or abnormal background3. Any evidence of progressive or symptomatic myoclonus epilepsy or focal seizures 4. Global learning disability 5. Dysmorphic syndrome6. Unable to provide informed consent
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Miss
Holly
Crudgington
+44 (0)20 7848 5162
Holly.crudgington@kcl.ac.uk
Prof
Deb
Pal
More information about this study, what is involved and how to take part can be found on the study website.
The study is sponsored by King’s College London; King's College Hospital NHS Trust and funded by Canadian Institutes of Health Research.
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
