Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Prof Naeem Soomro
+44 (0)191 2137597
partial@abdn.ac.uk


Prof Rakesh Heer
+44 (0)191 2084300
partial@abdn.ac.uk


Ms Diana Johnson
+44 (0)1224 438144
partial@abdn.ac.uk


More information about this study, what is involved and how to take part can be found on the study website.

Study Location:

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Be Part of Research - Trial Details - Is partial removal of the kidney better than removing the whole kidney for patients with intermediate-size kidney tumours?

Is partial removal of the kidney better than removing the whole kidney for patients with intermediate-size kidney tumours?

Medical Conditions

Renal cancer


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.



Background and study aims
PARTIAL is a research study looking at two different types of surgery for kidney cancer. Every year, over 13,000 people in the UK have a tumour on their kidney: some of these are kidney cancer, and others turn out not to be cancer. Often, these tumours are identified when they are at the early stages of growth (up to 7cm), and if there is no spread to other parts of the body the two main types of surgery that can be done are the removal of the whole kidney if there is a normal kidney on the other side (radical nephrectomy) and partial removal of the kidney where only part of the kidney (where the tumour is) is removed (partial nephrectomy). Each of these types of surgery has potential benefits and risks, but there is no good evidence for doctors and surgeons working in the NHS about which operation is better. When surgeons remove part of the kidney, there is a higher chance of bleeding, but in the longer term, the person’s kidney function may be better. It is also unclear which type of surgery is the best option for patients. The PARTIAL study will compare these two different types of surgery to answer the question of whether a partial removal of the kidney is better than removing the whole kidney for a group of more complex kidney tumours suitable for either approach.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

01 Jan 2023 30 Jun 2025

Adults who consent to participate in PARTIAL will be randomly allocated to one of the two types of surgery mentioned above. We will keep in touch with participants for 24 months to collect information on several things, including how well the kidney(s) are working (through regular blood tests), any complications of surgery and quality of life.


Adult patients in the UK with suspected or confirmed stage T1 renal cell carcinoma (a type of kidney cancer), who are suitable to have either operation by keyhole surgery

You can take part if:



You may not be able to take part if:


1. Solitary functioning kidney2. Metastatic disease3. Existing Chronic Kidney Disease (> stage 3b; eGFR< 45)4. Medically unfit for surgery5. Congenital renal abnormality which includes fusion, assent and malrotation6. Suspected or confirmed inherited kidney cancer syndrome7. Current pregnancy or breastfeeding8. People without capacity


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Freeman Road Hospital
    Freeman Road High Heaton
    Newcastle upon Tyne
    NE7 7DN
  • Leeds Teaching Hospitals NHS Trust
    St. James's University Hospital Beckett Street
    Leeds
    LS9 7TF
  • Aberdeen Royal Infirmary
    Foresterhill Road
    Aberdeen
    AB25 2ZN
  • University Hospital of Wales
    Heath Park
    Cardiff
    CF14 4XW
  • Royal Hallamshire Hospital
    Glossop Road
    Sheffield
    S10 2JF
  • Royal Free London NHS Foundation Trust
    Royal Free Hospital Pond Street
    London
    NW3 2QG
  • Churchill Hospital
    Old Road Headington
    Oxford
    OX3 7LE
  • Derriford Hospital
    Derriford Road
    Plymouth
    PL6 8DH
  • Western General Hospital
    Crewe Road South Edinburgh
    Lothian
    EH4 2XU
  • Russells Hall Hospital
    Pensnett Road
    Dudley
    DY1 2HQ
  • Sunderland Royal Hospital
    Kayll Road
    Sunderland
    SR4 7TP
  • Norfolk & Norwich University Hospital
    Colney Lane Colney
    Norwich
    NR4 7UY
  • Manchester Royal Royal Infirmary
    Cobbett House Oxford Road
    Manchester
    M13 9WL
  • Victoria Hospital
    Hayfield Road
    Kirkcaldy
    KY2 5AH
  • University Hospitals of Derby and Burton NHS Foundation Trust
    Royal Derby Hospital Uttoxeter Road
    Derby
    DE22 3NE
  • Liverpool University Hospitals NHS Foundation Trust
    Royal Liverpool University Hospital Prescot Street
    Liverpool
    L7 8XP
  • Leicester General Hospital
    Gwendolen Road
    Leicester
    LE5 4PW
  • Charing Cross Hospital
    Fulham Palace Road
    London
    W6 8RF
  • Addenbrookes Hospital
    Hills Road
    Cambridge
    CB2 0QQ
  • Pinderfields Hospital
    Aberford Road
    Wakefield
    WF1 4DG
  • East Kent Hospitals University NHS Foundation Trust
    Kent & Canterbury Hospital Ethelbert Road
    Canterbury
    CT1 3NG
  • Eastbourne District General Hospital
    Kings Drive
    Eastbourne
    BN21 2UD
  • Guys Hospital
    Great Maze Pond
    London
    SE1 9RT
  • The Royal Marsden Hospital (london)
    Fulham Road
    London
    SW3 6JJ
  • Royal Devon & Exeter Hospital (wonford)
    Barrack Road
    Exeter
    EX2 5DW
  • Stepping Hill Hospital
    Poplar Grove Hazel Grove
    Stockport
    SK2 7JE
  • Southend University Hospital
    Prittlewell Chase
    Westcliff-On-Sea
    SS0 0RY
  • Gartnavel General Hospital
    1053 Great Western Road
    Glasgow
    G12 0YN
  • Arrowe Park Hospital (site)
    Arrowe Park Hospital Arrowe Park Road
    Wirral
    CH49 5PE
  • Princess Royal Hospital
    Lewes Road
    Haywards Heath
    RH16 4EX
  • Centre for Healthcare Randomised Trials (CHaRT)
    Health Sciences Building University of Aberdeen Foresterhill
    Aberdeen
    AB25 2ZD
  • Walsgrave Hospital
    Clifford Bridge Road
    Coventry
    CV2 2DX
  • Royal Wolverhampton Hospital
    Wolverhampton Road
    Wolverhampton
    WV10 0QP
  • St Georges University Hospital Laboratory
    St. Georges Hospital Blackshaw Road
    London
    SW17 0QT

PARTIAL is a research study looking at two different types of surgery for kidney cancer. Every year, over 13,000 people in the UK have a tumour on their kidney: some of these are kidney cancer, and others turn out not to be cancer. Often, these tumours are identified when they are at the early stages of growth (up to 7cm), and if there is no spread to other parts of the body the two main types of surgery that can be done are the removal of the whole kidney if there is a normal kidney on the other side (radical nephrectomy) and partial removal of the kidney where only part of the kidney (where the tumour is) is removed (partial nephrectomy). Each of these types of surgery has potential benefits and risks, but there is no good evidence for doctors and surgeons working in the NHS about which operation is better. When surgeons remove part of the kidney, there is a higher chance of bleeding, but in the longer term, the person’s kidney function may be better. It is also unclear which type of surgery is the best option for patients. The PARTIAL study will compare these two different types of surgery to answer the question of whether a partial removal of the kidney is better than removing the whole kidney for a group of more complex kidney tumours suitable for either approach.
Both types of surgery are already being used in the NHS to treat patients who need kidney surgery. There are risks associated with all surgical procedures but there should be no additional risk in taking part in the study. Participants may not benefit personally from taking part but, by taking part, will help inform the treatment of future patients who need to have kidney surgery. The results of the PARTIAL study will help doctors, surgeons, patients and health services decision-makers understand whether it is better to remove the whole kidney or part of the kidney.

Ms Diana Johnson
+44 (0)1224 438144
partial@abdn.ac.uk


Prof Naeem Soomro
+44 (0)191 2137597
partial@abdn.ac.uk


Prof Rakesh Heer
+44 (0)191 2084300
partial@abdn.ac.uk



More information about this study, what is involved and how to take part can be found on the study website.


The study is sponsored by Newcastle upon Tyne Hospitals NHS Foundation Trust and funded by Health Technology Assessment Programme.




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Read full details for Trial ID: ISRCTN11293415

Or CPMS 54664

Last updated 23 April 2025

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