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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Dr Karthick Manoharan
+44 (0)1273 696955
karthick.manoharan1@nhs.net


Dr Karthick Manoharan
+44 (0)1273 696955
karthick.manoharan1@nhs.net


Dr Karthick Manoharan
+44 (0)1273 696955
karthick.manoharan1@nhs.net


Study Location:

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Be Part of Research - Trial Details - Mapping the inside and outside of the heart for patients with recurring atrial fibrillation
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Mapping the inside and outside of the heart for patients with recurring atrial fibrillation

Recruiting

Open to: All Genders

Age: Adult

Brighton

Medical Conditions

Atrial fibrillation

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Atrial fibrillation (AF) is the most common sustained abnormal heart rhythm which can increase the likelihood of other illnesses and death. This has been treated in the past with medication and resetting the heart rhythm with an electrical impulse in a process known as cardioversion, with mixed long-term success. An advance was the realisation that short-circuits in the electrical pathways in the heart that caused the abnormal rhythms could be broken by introducing a small scar across these pathways on the inside of the heart in a process known as cardiac ablation. However, symptoms can still reoccur and the aim of this study is to assess if ablation to the inside and outside of the heart in both upper chambers of the heart can decrease the chances of AF reoccurring.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

23 Jul 2023 01 Dec 2024

If suitable for the procedure the patient will have catheter ablation to both the inside and outside of the heart in areas of the upper heart chambers where there is evidence of reconnection of abnormal pathways. The patient will then be followed up at 6 months and 12 months to assess if there has been any reoccurrence of AF. An MRI scan prior to the procedure and at 12 months are optional and dependent on the participant’s consent.


Adults aged over 18 years old who have persistent AF and are suitable for catheter ablation

You can take part if:



You may not be able to take part if:


1. Pregnancy2. Current enrolment in another trial3. Clinically unsuitable4. Patients lacking capacity


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Brighton and Sussex University Hospitals NHS Trust
    Royal Sussex County Hospital Eastern Road
    Brighton
    BN2 5BE

Patients could benefit from there being less chance of their AF recurring. The additional risks of taking part in this study are inflammation and pain from the mapping and ablation of the outside of the heart, called pericarditis (1-2 in 100 people). This can sometimes occur with ablation to only the inside of the heart (1 in 200). There is also a risk of introducing infection into the outside space of the heart (1 in 100 people). We will administer antibiotics before the procedure and steroids after the procedure to minimise the risk of inflammation/pericarditis and infection.

Dr Karthick Manoharan
+44 (0)1273 696955
karthick.manoharan1@nhs.net


Dr Karthick Manoharan
+44 (0)1273 696955
karthick.manoharan1@nhs.net


Dr Karthick Manoharan
+44 (0)1273 696955
karthick.manoharan1@nhs.net



The study is sponsored by University Hospitals Sussex NHS Foundation Trust and funded by Abbott Laboratories.



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What will you do next?
Read full details for Trial ID: ISRCTN12869899

Or CPMS 55518

Last updated 26 February 2024

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.   

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