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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Intervention for venous stenosis in arteriovenous grafts
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The kidneys perform a vital function in regulating many chemicals and water in the blood. When the kidneys become diseased, these functions may be affected and if severe enough, can lead to a life-threatening build up of chemicals and water in the body. Whilst a kidney transplant is the ideal treatment for this, most patients with kidney failure require a period of dialysis. Dialysis is where blood is removed from the body, cleaned in a dialysis machine, then returned. A good connection to the machine to allow blood removal and return is the key, and this is called vascular access. Given how important this is, vascular access is often called a patient’s lifeline.
Arteriovenous grafts (AVG) have increasingly been used to provide vascular access for dialysis. The most common problem with AVG is narrowing at the join of the AVG to a vein (venous stenosis). The traditional treatment for venous stenosis is to stretch this narrowed area with a balloon – an angioplasty. Whilst this works well in the short term, the narrowing often comes back and then needs more treatments. A new treatment for venous stenosis has been developed called a stent graft that can be placed at the same time as the angioplasty. The stent graft is a small metal cage, lined by graft material that acts as a support to stop the narrowing from coming back. Several studies have shown that a stent graft can reduce the number of treatments needed but is not clear whether it is better to use them straight away, rather than
wait till after venous stenosis recurs after an angioplasty. The aim of this study is to see which is the best first treatment for venous stenosis – an angioplasty or a stent graft.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
You can take part if:
You may not be able to take part if:
1. Pregnant female at the time of informed consent signature.2. AVG implanted less than 4 weeks previously.3. A plan for conversion to alternative form of renal replacement therapy within 60 days.4. A history or evidence of severe systemic disease including:4.1. History of cancer (excludes BCC) with active disease or active anti-tumor (cytotoxic) treatment within the previousyear;4.2. Suspected or documented hyper-coagulable state, unless willing to take anti-coagulation;4.3. Recurrent (>1/year) unexplained thrombotic episodes;5. Known or suspected central vein stenosis / occlusion on the side of AVG.6. Treatment with any investigational drug within 60 days prior to study entry.7. Any condition that in the judgment of the investigator would preclude adequate evaluation of the trial end points.8. Unwilling or unable to have regular surveillance.
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Prof
David
Kingsmore
+44 1414515941
clare.dolan3@ggc.scot.nhs.uk
The study is sponsored by NHS Greater Glasgow and Clyde and funded by Kidney Research UK.
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Or CPMS 54767
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
