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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Prof
John
Hurst
+44 208 016 8364
j.hurst@ucl.ac.uk
Prof
Mona
Bafadhel
+44 207 848 0606
mona.bafadhel@kcl.ac.uk
Dr
Olena
Said
+44 20 7848 0532
olena.said@kcl.ac.uk
More information about this study, what is involved and how to take part can be found on the study website.
Chronic obstructive pulmonary disease (COPD)
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease affecting approximately 10% of the adult population globally. COPD is recognised to be an important area of focus, as part of one of the healthcare challenges defined by the Office of Life Sciences. Patients with COPD often experience exacerbations which are triggered
episodes leading to disease worsening. Exacerbations are associated with increased morbidity and a risk of mortality.
Severe exacerbations, where patients are hospitalised, are of particular concern to patients, carers and healthcare givers. The National Institute for Health and Care Excellence (NICE) recommends that hospital clinicians looking after patients with COPD should provide rescue packs (a course of prednisolone and antibiotics) and a basic management
plan to patients on discharge. It is recognised that there is a high-risk 90-day period to patients with COPD following discharge from hospital, where there is a 43% risk of readmission and a 12% risk of mortality; however repeated national audit data has shown that, despite NICE recommendations this high risk of readmission and mortality has
not changed.
We will conduct a multicentre randomised clinical trial of 1400 patients in 30 acute NHS trusts. This will test the hypothesis that a self-supported rescue pack management plan consisting of rescue packs + written self-management plan + twice weekly telephone/text symptom alert assessments in the high-risk 90-day period is better than standard care in reducing 90-day readmission by 20%. If successful, this intervention would be rapidly implementable, improve patient clinical outcomes and have a cost saving of approximately £350 million per annum.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
You can take part if:
You may not be able to take part if:
Current participant exclusion criteria as of 07/02/2025: 1. Requirement for invasive ventilation during the hospital admission2. Patients with signs of new consolidation on chest X-ray (if available)3. Patients who have an expected survival of less than 90 days4. Discharge to a residential or nursing home5. Inability to engage with supported self-management6. No access to telephone7. Participation in another intervention study8. Previous participation in the RAPID trial.
Previous participant exclusion criteria as of 28/11/2024 to 07/02/2025: 1. Requirement for invasive ventilation during the hospital admission2. Patients who have an expected survival of less than 90 days3. Discharge to a residential or nursing home4. Inability to engage with supported self-management5. No access to telephone6. Participation in another intervention study
Previous participant exclusion criteria:1. Requirement for invasive ventilation during the hospital admission2. Patients who have an expected survival of less than 90 days3. Discharge to a residential or nursing home4. Inability to engage with supported self-management5. No access to telephone6. Participation in another intervention study7. Individuals discharged from hospital to a non-physical virtual ward
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Dr
Olena
Said
+44 20 7848 0532
olena.said@kcl.ac.uk
Prof
John
Hurst
+44 208 016 8364
j.hurst@ucl.ac.uk
Prof
Mona
Bafadhel
+44 207 848 0606
mona.bafadhel@kcl.ac.uk
More information about this study, what is involved and how to take part can be found on the study website.
The study is sponsored by King's College London; Guy's and St Thomas' NHS Foundation Trust and funded by NIHR Evaluation, Trials and Studies Co-ordinating Centre (NETSCC).
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Or CPMS 63008
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
