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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Christine Le Maitre
c.lemaitre@sheffield.ac.uk


Christine Le Maitre
c.lemaitre@sheffield.ac.uk


Claire Christmas
c.christmas@sheffield.ac.uk


Dominic Nash
dominic.nash@nhs.net


Study Location:

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Be Part of Research - Trial Details - Pathogenesis of disc degeneration

Pathogenesis of disc degeneration

Recruiting

Open to: All Genders

Age: 18 Years - 80 Years

Medical Conditions

Other dorsopathies


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Low back pain is a major problem in the community affecting 80% of the population at some point in their life. In a high
proportion of cases the pain is a result of damage to the discs of the spine,which in the normal spine provided the
flexibility and shock absorbing properties of the spine. However to date,the complex pathways involved in causing the
damage to the discs and generation of pain are not fully understood. In order for the successful development of new
therapies to treat low back pain these need to be targeted to the causes of the damage. This study aims to investigate
the involvement of a number of protiens,known as cytokines and chemokines which are thought to be involved in
regulating the damage seen during low back pain,together with other proteins suggested to be involved. We also
intend to investigate the mechanisms involved in controlling the production and activity of these factors with the hope to
develop new targeted therapies to treat the damaged disc and thus low back pain.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

09 Aug 2023 16 Jan 2026

Observational

Observational type: Clinical Laboratory Study;



You can take part if:



You may not be able to take part if:


n/a


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Northern General Hospital
    Herries Road
    Sheffield
    South Yorkshire
    S5 7AU

Christine Le Maitre
c.lemaitre@sheffield.ac.uk


Claire Christmas
c.christmas@sheffield.ac.uk


Christine Le Maitre
c.lemaitre@sheffield.ac.uk


Dominic Nash
dominic.nash@nhs.net



The study is sponsored by University of Sheffield and funded by European Commission .




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for Trial ID: CPMS 56207

Last updated 28 March 2025

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