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Be Part of Research - Trial Details - A Study of Aticaprant 10 Milligrams (mg) as Adjunctive Therapy in Adult Participants With MDD With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy

A Study of Aticaprant 10 Milligrams (mg) as Adjunctive Therapy in Adult Participants With MDD With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy

Completed

Open to: ALL

Age: 18.0 - 74.0

Medical Conditions

Anhedonia
Depressive Disorder
Depression
Depressive Disorder, Major


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this study is to evaluate the efficacy of aticaprant compared with placebo as adjunctive therapy to an antidepressant in improving depressive symptoms in adult participants with major depressive disorder (MDD) with moderate to severe anhedonia (ANH+) who have had an inadequate response to current antidepressant therapy with a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI).

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Dec 2022 Nov 2024

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Aticaprant tablet will be administered orally.

Intervention Arm Group : Aticaprant;

Intervention Type : OTHER
Intervention Description : Placebo tablet will be administered orally.

Intervention Arm Group : Placebo;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Institute of Psychiatry
    London
    SE5 8AF
  • Royal Edinburgh Hospital
    Edinburgh
    EH10 5HF
  • Moorgreen Hospital
    Southampton
    SO30 3JB
  • Renfrewshire CMHT
    Paisley
    PA1 1JS
  • University of Sussex
    Brighton
    BN1 9RY
  • Crisis Resolution and Home Treatment Team
    Wigan And Leigh
    WN7 1YN


The study is sponsored by Janssen Research & Development, LLC




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Read full details for Trial ID: NCT05550532
Last updated 25 April 2025

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