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Be Part of Research - Trial Details - Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations

Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations

Not Recruiting

Open to: ALL

Age: 40.0 - 130.0

Medical Conditions

Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this Phase III study is to evaluate the efficacy and safety of tozorakimab administered subcutaneously (SC) in adult participants with symptomatic COPD with a history of ≥ 2 moderate or ≥ 1 severe exacerbations of COPD in the 12 months prior to enrolment. Participants should be receiving optimised treatment with inhaled maintenance therapy (ICS/LABA/LAMA triple therapy, or dual therapy if triple is not considered appropriate) throughout at least the last 3 months prior to enrolment.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Sep 2023 Mar 2026

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Placebo administered subcutaneously, equivalent volume to tozorakimab throughout the study.

Intervention Arm Group : Placebo;

Intervention Type : DRUG
Intervention Description : Administered subcutaneously tozorakimab and placebo throughout the study.

Intervention Arm Group : Tozorakimab;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Research Site
    London
    EC1M 6BQ
  • Research Site
    Glasgow
    G4 0SF
  • Research Site
    London
    NW3 2QG
  • Research Site
    Cottingham
    HU16 5JQ
  • Research Site
    Leeds
    LS9 7TF
  • Research Site
    Bradford
    BD9 6RJ
  • Research Site
    Wakefield
    WF1 4DG
  • Research Site
    Liverpool
    L7 8XP
  • Research Site
    Portsmouth
    PO6 3LY
  • Research Site
    Newcastle upon Tyne
    NE7 7AF
  • Research Site
    Macclesfield
    SK10 3BL


The study is sponsored by AstraZeneca




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Read full details for Trial ID: NCT06040086
Last updated 17 March 2025

This page is to help you find out about a research study and if you may be able to take part

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