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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Dermot Linden, PhD
07812008626
dlinden02@qub.ac.uk
Danny McAuley, MD
+442890 972144
d.f.mcauley@qub.ac.uk
Pneumonia Lung Injury Acute Lung Injury Inflammation Hyperoxia Wounds and Injuries
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Oxygen is the most commonly administered therapy in critical illness. Accumulating evidence suggests that patients often achieve supra-physiological levels of oxygenation in the critical care environment. Furthermore, hyperoxia related complications following cardiac arrest, myocardial infarction and stroke have also been reported. The underlying mechanisms of hyperoxia mediated injury remain poorly understood and there are currently no human in vivo studies exploring the relationship between hyperoxia and direct pulmonary injury and inflammation as well as distant organ injury.
The current trial is a mechanistic study designed to evaluate the effects of prolonged administration of high-flow oxygen (hyperoxia) on pulmonary and systemic inflammation. The study is a randomised, double-blind, placebo-controlled trial of high-flow nasal oxygen therapy versus matching placebo (synthetic medical air). We will also incorporate a model of acute lung injury induced by inhaled endotoxin (LPS) in healthy human volunteers. Healthy volunteers will undergo bronchoalveolar lavage (BAL) at 6 hours post-intervention to enable measurement of pulmonary and systemic markers of inflammation, oxidative stress and cellular injury.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
You can take part if:
You may not be able to take part if:
This is in the inclusion criteria above
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Dermot Linden, PhD
07812008626
dlinden02@qub.ac.uk
Danny McAuley, MD
+442890 972144
d.f.mcauley@qub.ac.uk
The study is sponsored by Belfast Health and Social Care Trust
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
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