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Be Part of Research - Trial Details - Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations.

Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations.

Not Recruiting

Open to: ALL

Age: 40.0 - 130.0

Medical Conditions

Chronic Obstructive Pulmonary Disease (COPD)


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this Phase III study is to evaluate the efficacy and safety of tozorakimab Dose 1 and Dose 2 administered subcutaneously (SC) in adult participants with symptomatic COPD and history of ≥ 2 moderate or ≥ 1 severe exacerbation of COPD in the previous 12 months. Participants should be receiving optimised treatment with maintenance inhaled therapy (ICS/LABA/LAMA triple therapy, or dual therapy if triple is not considered appropriate) in stable doses throughout at least 3 months prior to enrolment.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Feb 2022 Jan 2026

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Administered subcutaneously tozorakimab Dose 1 and placebo through Week 52.

Intervention Arm Group : Tozorakimab Dose 1;

Intervention Type : DRUG
Intervention Description : Administered subcutaneously tozorakimab Dose 2 through Week 52.

Intervention Arm Group : Tozorakimab Dose 2;

Intervention Type : DRUG
Intervention Description : Placebo administered subcutaneously, equivalent volume to tozorakimab through week 52.

Intervention Arm Group : Placebo;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Research Site
    Northwood
    HA6 2RN
  • Research Site
    Bradford
    BD9 6RJ
  • Research Site
    Corby
    NN18 9EZ
  • Research Site
    Preston
    PR2 9QB
  • Research Site
    High Wycombe
    HP11 2QW
  • Research Site
    Hampshire
    SO16 6YD
  • Research Site
    Shipley
    BD18 3SA
  • Research Site
    Corby
    NN17 2UR
  • Research Site
    Enfield
    EN3 4GS


The study is sponsored by AstraZeneca




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Read full details for Trial ID: NCT05158387
Last updated 15 January 2026

This page is to help you find out about a research study and if you may be able to take part

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