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English | Cymraeg
Be Part of Research - Trial Details - A Study of Vaccination With 9-valent Extraintestinal Pathogenic Escherichia Coli Vaccine (ExPEC9V) in the Prevention of Invasive Extraintestinal Pathogenic Escherichia Coli Disease in Adults Aged 60 Years And Older With a History of Urinary Tract Infection in the Past 2 Years

A Study of Vaccination With 9-valent Extraintestinal Pathogenic Escherichia Coli Vaccine (ExPEC9V) in the Prevention of Invasive Extraintestinal Pathogenic Escherichia Coli Disease in Adults Aged 60 Years And Older With a History of Urinary Tract Infection in the Past 2 Years

Medical Conditions

Urinary Tract Infections
Escherichia coli Infections


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this study is to demonstrate the efficacy of 9-valent extraintestinal pathogenic Escherichia coli vaccine (ExPEC9V) compared to placebo in the prevention of the first invasive extraintestinal pathogenic Escherichia coli disease (IED) event caused by ExPEC9V O-serotypes.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jun 2021 Aug 2025

INTERVENTIONAL

Intervention Type : BIOLOGICAL
Intervention Description : ExPEC9V will be administered as an IM injection.

Intervention Arm Group : ExPEC9V;

Intervention Type : OTHER
Intervention Description : Matching placebo will be administered as an IM injection.

Intervention Arm Group : Placebo;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • South Tees Hospitals NHS Foundation Trust
    Middlesbrough
    TS4 3BW
  • Manchester Royal Infirmary
    Manchester
    M13 9WL
  • Royal Bournemouth Hospital
    Bournemouth
    BH7 7DW
  • North Bristol NHS Trust
    Bristol
    BS10 5NB
  • King's College Hospital NHS Foundation Trust
    London
    SE5 9RS
  • Aberdeen Royal Infirmary
    Aberdeen
    AB25 2ZN
  • Royal Devon & Exeter NHS Foundation Trust
    Exeter
    EX2 5DW
  • Nottingham University Hospitals NHS Trust
    Nottingham
    NG7 2UH
  • Blackpool Teaching Hospitals NHS Foundation Trust
    Blackpool
    FY3 8NR
  • The Adam Practice
    Poole
    BH15 4JQ
  • Atherstone Surgery
    Atherstone
    CV9 1EU
  • Banbury Cross Health Center
    Banbury
    OX16 9AD
  • FutureMeds Bridle Clinic
    Birkenhead
    CH62 6EE
  • FutureMeds-Soho UK
    Birmingham
    B21 0RY
  • University Hospitals Bristol NHS Trust
    Bristol
    BS2 8BJ
  • Eynsham Medical Centre
    Eynsham
    OX29 4QB
  • The Garth Surgery
    Guisborough
    TS14 7DJ
  • The NIHR Manchester Clinical Research Facility
    Manchester
    M23 9LT
  • Plymouth University Hospitals Trust
    Plymouth
    PL6 8DH
  • Ashgrove Surgery
    Pontypridd
    CF37 2DR
  • Sheffield Teaching Hospitals NHS Foundation Trust
    Sheffield
    S10 2 JF
  • Midlands Partnership NHS Foundation Trust
    Stafford
    ST16 3SR
  • Mid Yorkshire Hospital NHS Trust- Pinderfields Hospital
    Wakefield
    WF1 4DG
  • Church Street Practice
    Wantage
    OX12 9BN
  • Windrush Medical Practice
    Witney
    OX28 6JS
  • North Tees Furturemeds
    Stockton-on-Tees
    TS19 8PE
  • University Hospitals Of Leicester Nhs Trust
    Leicester
    LE1 5WW


The study is sponsored by Janssen Research & Development, LLC




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Read full details for Trial ID: NCT04899336
Last updated 08 April 2025

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