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Be Part of Research - Trial Details - A Study to Investigate the Efficacy and Safety of Baxdrostat in Participants With Uncontrolled Hypertension on Two or More Medications Including Participants With Resistant Hypertension

A Study to Investigate the Efficacy and Safety of Baxdrostat in Participants With Uncontrolled Hypertension on Two or More Medications Including Participants With Resistant Hypertension

Not Recruiting

Open to: ALL

Age: 18.0 - 130.0

Medical Conditions

Hypertension


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This is a Phase III, multicentre, randomised, double-blinded, placebo-controlled, parallel group study to evaluate the safety, tolerability and effect of 1 or 2 mg baxdrostat versus placebo, administered once daily (QD) orally, on the reduction of systolic blood pressure in approximately 720 participants aged ≥ 18 years with hypertension, despite a stable regimen of 2 antihypertensive agents at baseline, one of which is a diuretic (uncontrolled hypertension); or ≥ 3 antihypertensive agents at baseline, one of which is a diuretic (treatment-resistant hypertension).

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Nov 2023 Jun 2025

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Baxdrostat tablet administered orally, once daily (QD). Unit dose strengths:

* 1 mg per tablet for 1 mg baxdrostat Arm;* 2 mg per tablet for 2 mg baxdrostat Arm.

Intervention Arm Group : 1 mg baxdrostat;2 mg baxdrostat;

Intervention Type : DRUG
Intervention Description : Placebo tablet matching baxdrostat, administered orally, once daily (QD).

Intervention Arm Group : Placebo;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Research Site
    Chesterfield
    S40 4AA
  • Research Site
    London
    EC1M 6BQ
  • Research Site
    Dundee
    DD1 9SY
  • Research Site
    Glasgow
    G51 4TF
  • Research Site
    Prescot
    L35 5DR
  • Research Site
    Bristol
    BS34 6BQ
  • Research Site
    Yate
    BS37 4AX
  • Research Site
    London
    W6 7HY
  • Research Site
    Harrow
    HA3 7LT
  • Research Site
    Bollington
    SK10 5JH
  • Research Site
    Hownslow
    TW3 3LN
  • Research Site
    Weston-Super-Mare
    BS24 7PR


The study is sponsored by AstraZeneca




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Read full details for Trial ID: NCT06034743
Last updated 21 March 2025

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