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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Carcinoma Neoplasms Multiple Myeloma Thyroid Neoplasms Colorectal Neoplasms Carcinoma, Non-Small-Cell Lung Ovarian Neoplasms Hematologic Neoplasms Laryngeal Neoplasms Thyroid Cancer, Papillary Thyroid Carcinoma, Anaplastic Erdheim-Chester Disease Thyroid Diseases
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
This clinical trial is looking at a combination of drugs called vemurafenib and cobimetinib. Vemurafenib is approved as standard of care for adult patients with unresectable or metastatic melanoma. Cobimetinib is approved as standard of care in combination with vemurafenib for the treatment of adult patients with unresectable or metastatic melanoma.
Cobimetinib and vemurafenib work in patients with these types of cancers which have certain changes in the cancer cells called BRAF V600 mutation-positive.
Investigators now wish to find out if it will be useful in treating patients with other cancer types which are also BRAF V600 mutation-positive. If the results are positive, the study team will work with the NHS and the Cancer Drugs Fund to see if these drugs can be routinely accessed for patients in the future.
This trial is part of a trial programme called DETERMINE. The programme will also look at other anti-cancer drugs in the same way, through matching the drug to rare cancer types or ones with specific mutations.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
You can take part if:
You may not be able to take part if:
This is in the inclusion criteria above
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Aida Sarmiento Castro
+442034695101
determine@cancer.org.uk
The study is sponsored by Cancer Research UK and is in collaboration with University of Manchester; University of Birmingham; Royal Marsden NHS Foundation Trust; Hoffmann-La Roche.
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
