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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Disorders of other endocrine glands
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Hypertension (high blood pressure) costs £2.1 billion per year for our NHS, and causes damage to vital organs
meaning you are 75% more likely to develop other heart and blood vessel disease. Hypertension in women is
sometimes caused by polycystic ovary syndrome (PCOS). PCOS affects up to 20% of all women in the UK, and can
also result in problems getting pregnant. Normally, everyone’s blood pressure is controlled by the nervous system, but
overactivity of the ‘fight of flight’ arm of this control system is one of the causes of hypertension. As yet, however, we
don’t know whether this is true in PCOS patients. The condition is known to disrupt the normal balance of hormones
that are thought to influence the nervous system activity, and could have a detrimental impact on blood pressure.
Importantly, PCOS patients are often not diagnosed until they try to conceive, but these hormonal changes happen
during the adolescent period and may disrupt blood pressure regulation and increase disease risk from an early age.
This project will be the first to assess blood pressure regulation in girls with high androgens and in PCOS patients
before and after a single dose drug intervention to block the effect of androgen hormones. This research will work out
how much influence these hormone changes have on blood pressure regulation in PCOS. Understanding these
things is crucial for successful treatment, preventing deaths and reducing NHS cost-burden from PCOS patients with
hypertension.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Interventional type: Drug;Other;
You can take part if:
You may not be able to take part if:
• diagnosed cardiovascular/pulmonary/neural disease; • pregnancy if sexually active (confirmed by pregnancy test at each visit)/breastfeeding/seeking pregnancy; • any medication that affects central nervous system or vascular function (oral contraceptives, anti-hypertensives, anti-androgens, lipid lowering medication); • any other conditions causing hyperandrogenism (congenital adrenal hyperplasia, Cushing’s syndrome).
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by Cardiff Metropolitan University and funded by ACADEMY OF MEDICAL SCIENCES .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 54722
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
